Professor Emma Raven
BSci (Leic.), PhD(N'cle)
Current positions
Academic Director (REF)
Science Faculty OfficeProfessor
School of Chemistry
Contact
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Research interests
The work of my research is to understand the catalytic activity and biological function in heme containing enzymes. Heme is the prosthetic group found in a number of biologically important proteins (from haemoglobin to catalases) which have a diverse range of biological functions including electron transfer, transportation of gases and chemical catalysis. Our work is focused in three main areas: peroxidases, dioxygenases and the role of heme in the cell. We use kinetic and spectroscopic methods to understand the mechanism and function of heme enzymes, and we collaborate with structural biologists (Prof Peter Moody, University of Leicester) to provide a structural framework for our experiments.
Projects and supervisions
Research projects
International partnerships award to develop new collaborations in Raven laboratory (project code IIPF2024-02)
Principal Investigator
Managing organisational unit
School of ChemistryDates
04/01/2024 to 29/06/2024
BBSRC International Partnerships Fund
Principal Investigator
Managing organisational unit
School of ChemistryDates
01/11/2022 to 31/03/2023
Understanding supply and demand for heme in cells
Principal Investigator
Managing organisational unit
School of ChemistryDates
01/04/2022 to 31/03/2026
8082 BBSRC Japan Partnering award BB/S020586/1
Principal Investigator
Managing organisational unit
School of ChemistryDates
01/07/2019 to 30/06/2023
A Bristol-RIKEN partnership to exploit the SACLA free electron laser
Principal Investigator
Description
The aim of this application is to establish a long-term collaboration with the groups at Spring-8/Hyogo University. Spring-8 is the world’s largest third generation synchrotron facility and the home of…Managing organisational unit
School of ChemistryDates
01/05/2019 to 31/07/2019
Thesis supervisions
A framework for the investigation of heme homeostasis through genetically encoded heme sensors
Supervisors
Exploration into the use of bioinformatics and genetically encoded sensors to understand the binding and dynamics of heme in the cell
Supervisors
Enzymatic Oxidation of Tryptophan and Its Analogues by Heme-Containing Dioxygenases
Supervisors
Publications
Recent publications
08/05/2024In silico prediction of heme binding in proteins
Journal of Biological Chemistry
Heme binding to the SARS-CoV-2 spike glycoprotein
Journal of Biological Chemistry
Binding of l-kynurenine to X. campestris tryptophan 2,3-dioxygenase
Journal of Inorganic Biochemistry
Understanding the Logistics for the Distribution of Heme in Cells
Journal of the American Chemical Society
Unravelling the mechanisms controlling heme supply and demand
Proceedings of the National Academy of Sciences