Dr Chrissy Hammond
We use zebrafish to unpick how skeletal diseases in people develop and progress
Associate Professor in Developmental GeneticsSchool of Physiology, Pharmacology & Neuroscience
Our group's research focuses on the regulation of cartilage and bone homeostasis in development and in disease states such as osteoarthritis, osteoporosis and Stickler syndrome as well as during repair and regeneration. We are particularly interested in the interplay between genes and environmental cues such as mechanical loading, diet, and metabolism. We use the zebrafish as a model because it combines excellent genetics with beautiful imaging possibilities, which allow us to study the development of the skeletal system dynamically in vivo.
We have a number of projects running in collaboration with clinicians, engineers and epidemiologists.
Additionally, with Emma Vincent, I colead an Elizabeth Blackwell Institute research strand called 'Mechanisms to Populations' which aims to help overcome the barriers to interdisciplinary work in epidmiology and functional biological studies. For mroe information on the strand please see:
01/01/2020 to 31/12/2024
01/10/2018 to 31/03/2019
Effect of treatment with Vitamin D and synthetic analogues in preventing intestine inflammatory disease and osteoarthritis in zebrafish larvae
DescriptionGut inflammation and disease, Osteoarthritis, Vitamin D
23/06/2018 to 31/07/2018
10/11/2017 to 09/05/2018
- Other contribution
3D assessment of intervertebral disc degeneration in zebrafish identifies changes to bone density that prime disc disease
- E-pub ahead of print
Exposure to hypergravity during zebrafish development alters cartilage material properties and strain distribution.
Bone and Joint Research
Journal of Cell Biology