Professor Alastair Poole
Vet.M.B., M.A., Ph.D.(Cantab.), M.R.C.V.S.
Current positions
Professor of Pharmacology and Cell Biology
School of Physiology, Pharmacology & Neuroscience
Contact
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Research interests
Platelets are the smallest cellular component of the blood and are an essential element in the primary haemostatic system. They are able to respond to a wide range of agonists and when activated at the site of blood vessel injury they rapidly aggregate to form a platelet haemostatic plug. Platelets are therefore of central importance in maintaining the physiological integrity of the vascular system and play a major role in the pathological development of thrombosis.
Our laboratory is interested in the cell biology of platelets, from the molecular through to the systems level. We are particularly interested in understanding how protein kinases may regulate platelet function and thrombus formation, and use a wide variety of techniques to address these questions.
Projects and supervisions
Research projects
8051 (MRC CiC Ref MC_PC_19031) Creating an immortalised iPSC line for platelet generation additonal costs
Principal Investigator
Managing organisational unit
School of Physiology, Pharmacology & NeuroscienceDates
01/02/2025 to 31/12/2025
Creating an immortalised iPSC line for platelet generation
Principal Investigator
Managing organisational unit
School of Physiology, Pharmacology & NeuroscienceDates
01/07/2023 to 30/09/2023
8051- PPN - Poole - EBI MRC CiC - Development of a novel scalable system to generate platelets for transfusion
Principal Investigator
Managing organisational unit
School of Physiology, Pharmacology & NeuroscienceDates
01/03/2021 to 30/04/2022
The Role of the Water Channel Aquaporin-1 in the Regulation of Platelet Function, Procoagulant activity and Thrombosis
Principal Investigator
Managing organisational unit
School of Physiology, Pharmacology & NeuroscienceDates
10/11/2017 to 09/11/2020
Flexible Talent Mobility Account
Principal Investigator
Managing organisational unit
School of Physiology, Pharmacology & NeuroscienceDates
01/11/2017 to 31/03/2019
Thesis supervisions
Investigating the health and function of murine platelets generated using a new ex-vivo lung system
Supervisors
The Effect of Hyperglycaemia and Thrombopoietin on Platelet Function
Supervisors
Identification and Elucidation of Novel Platelet Primers
Supervisors
Proteolysis Targeting Chimeras
Supervisors
Investigating In Vitro Platelet Production Through a Microscopy Lens
Supervisors
Insights into megakaryocyte biology from population platelet traits
Supervisors
Publications
Recent publications
24/10/2024Critical role for platelet Ral GTPases in regulating venous thrombosis in mice
Journal of Thrombosis and Haemostasis
CryoET reveals actin filaments within platelet microtubules
Nature Communications
Platelet generation in vivo and in vitro
Blood
Alterations in platelet proteome signature and impaired platelet integrin αIIbβ3 activation in patients with COVID-19
Journal of Thrombosis and Haemostasis
Highly efficient platelet generation in lung vasculature reproduced by microfluidics
Nature Communications