Big babies, little mothers: tsetse flies show extreme mothering
Press release issued: 4 November 2020
The tsetse fly is an exception to the almost universal law of nature that babies are born smaller than their mothers.
In an article published in BioEssays, Drs Sinead English and Antoine Barreaux from the University of Bristol’s School of Biological Sciences, together with colleagues at the Liverpool School of Tropical Medicine, and the Universities of Greenwich, Stellenbosch and California Riverside, explore the extreme reproductive strategy of tsetse flies - which sees mothers give birth to young that astoundingly are 100 per cent of their body size.
Across most of the animal kingdom, offspring are born smaller than their parents. Surprisingly, several insect families, including tsetse, are exceptions to this rule. This amazing feat is possible thanks to two main factors. First, tsetse feed exclusively on protein-rich blood and can consume more than twice their body weight every few days. Second, tsetse do not have the same constraint as mammals such as a fixed pelvic girdle, which prevents birthing of enormous babies.
Producing large offspring does, however, have a consequence that egg-laying insects do not face - female tsetse flies can birth only one baby at a time, at relatively long intervals. This results in a slow life history, in which the females must be continually pregnant and long-lived, if the number of offspring produced is to be enough to sustain the species.
Dr Lee Haines, lead author on the study, said: “The thought of a female giving birth to a single offspring that weighs more than she does is difficult to wrap your head around. Since we are familiar with human babies, which weigh ~6% of the mother’s pre-pregnancy weight, this feat is unthinkable.
“Now, imagine giving birth to a massive baby every ten days… for the rest of your life. This tremendous maternal investment raises the question of how natural selection could produce this seemingly impossible capacity. The unusual method of reproduction also carries enormous ramifications for tsetse biology, survival and the control of vector populations.”
Burrowing for knowlegde is a short documentary about the BBSRC/RS-funded project led by Professor Steve Torr at Liverpool School of Tropical Medicine and Dr Sinead English at the University of Bristol
Tsetse are not only fascinating from a biological perspective, but they are also a serious public health and veterinary threat because they transmit the micro-organisms responsible for the fatal human and animal diseases called African trypanosomiases. The essay discusses how the life history of the tsetse and its strange reproductive strategy directly influence the type of vector control interventions we can use to reduce fly populations and control the disease.
Since tsetse larvae remain protected within their mother’s uterus and the pupae are hidden in the soil, controlling tsetse populations is unfortunately restricted to targeting only adult flies. Thankfully, the tsetse’s slow breeding cycle means that you only need to kill a few percent of the adult female flies per day to eradicate any tsetse population. Currently, insecticide applied to cattle and artificial host-like baits, such as “tiny targets” are used successfully to control tsetse populations in disease-endemic areas. Other vector control strategies, like sterile insect techniques and microbiome-mediated control strategies, can be more challenging to implement due to the flies’ specialised reproductive strategy.
Dr Sinead English said: "Our project came about through my interest in the role of mothers in the natural world, and how they have such a pervasive effect on their offspring. It was during my own maternity leave when I had a chance meeting with tsetse expert, Professor John Hargrove, who convinced me that tsetse are the ultimate mothers. Our partnership then burgeoned into a truly international collaboration of researchers, across countries and across disciplines. Beyond disease control we are interested in how tsetse can have evolved such a fascinating reproductive system in the first place. Why would natural selection favour a strategy of producing such enormous young and how does the mother survive to go on to produce yet more offspring? We hope this research will inform and improve tsetse control, but also inspire fundamental questions about the evolution of pregnancy and motherhood more generally.”
Big Baby, Little Mother: Tsetse Flies Are Exceptions to the Juvenile Small Size Principle by Haines, L. et al. in BioEssays.
Life Sciences at the University of Bristol
The Faculty of Life Sciences brings together the five Schools of:
- Biological Sciences
- Cellular and Molecular Medicine
- Physiology, Pharmacology and Neuroscience
- Psychological Science
We have a long-standing tradition of excellence in research and teaching. Our broad range of expertise opens up a wealth of opportunities for all our students. Here you can study a range of challenging, research-focused, undergraduate and postgraduate programmes, all taught in the context of world-leading research environments, using specialist equipment and facilities.
Our research addresses a range of the important challenges in the life sciences. From tackling ecosystem and global change, to innovation in fundamental biosciences for better human, animal, plant and ocean health.
From understanding animal and human behaviour and wellbeing, to developing future synthetic biotechnologies and so driving the UK's bioeconomy.
We are changing the way we understand the fundamental principles of life and the natural world through a series of interrelated research themes. Underpinning these research themes is a world class state-of-the-art infrastructure for Imaging, 'Omics and informatics and Responsible research and innovation.
Early career research training in the faculty is supported by a powerful range of 3 and 4 year Doctoral Training Programmes.