Removing nerves connecting kidney to the brain shown to reduce high blood pressure

Press release issued: 2 July 2013

A new technique by a team at the University of Bristol that involves removing the nerves connecting the kidney to the brain has shown to significantly reduce blood pressure and help lower the risk of stroke, heart and renal disease in patients.

The technique, published in the journal Hypertension, was performed by a team led by Professor Julian Paton at the University of Bristol who found that in an animal model of hypertension removing nerves connecting the kidney to the brain reduced blood pressure and improved its long-term stability.

Inspired by these results, cardiologists Dr Angus Nightingale and Dr Andreas Baumbach from the Bristol Heart Institute (BHI) adopted the technique called “renal denervation” to remove the nerves to the kidney in patients with high blood pressure.

The procedure, which has been successfully trialled on 19 patients at the BHI, is performed using a fine tube that is inserted in an artery in the patient’s leg and positioned in the artery feeding blood to the patient’s kidneys. The nerves to the kidney are around the artery and ablated by radio-frequency energy that is emitted from the tube.

The breakthrough is due to a new collaboration involving scientists at the University of Bristol and cardiologists at the BHI, who have joined forces to form the CardioNomics high blood pressure team. Together, they hope to tackle this major health problem by taking findings from the laboratory and translating them into clinical practice. The CardioNomics team have just been awarded £100,000 grant from Medtronic to further improve the technique and expand patient trials.

Dr Nightingale, who runs the Specialist Hypertension Clinic at the BHI, said: “We have used renal denervation in patients who have hard-to-treat blood pressure. Similar to the results from the basic science experiments, we have also seen reductions in blood pressure which has been essential for reducing the risk of heart and renal disease, and stroke in our patients. This is an exciting new treatment for these patients who have struggled with high blood pressure which tablets are not controlling.”

Dr Baumbach, an interventional cardiologist who performed the treatment, added: “The technique is very straight forward, performed as a day case and there are no side-effects. It is becoming a popular technique for patients with both resistance and poor tolerability to high blood pressure medication.”

Professor Julian Paton, who led the research at the University’s School of Physiology and Pharmacology, said: “The problem with high blood pressure is that patients develop resistance to their tablets or unpleasant side effects. Our new interventional approaches are based on studies where we have found causative mechanisms generating high blood pressure so we think that they will be most efficacious in patients. And, with luck, they will also mean less pill taking too.”

This study is published in the journal Hypertension and is entitled ‘Translational examination of changes in baroreceptor reflex function after bilateral renal denervation in hypertensive rats and humans’. The hypertension research team at the Bristol Heart Institute specialises in treating patients with hypertension and is trialling numerous drug-free interventional therapies.

Further information

The Bristol NIHR Biomedical Research Unit for Cardiovascular Disease based in University Hospitals Bristol NHS Foundation Trust also contributed to this research.

The research was funded by the British Heart Foundation and Cibiem (New York), the Above & Beyond Charity and UHBristol Trust.

High blood pressure

High blood pressure is known as the world’s biggest silent killer because most people can’t “feel” their blood pressure going up. It affects around one in three people and can cause stroke, heart attacks and kidney failure. In England 32 per cent of men and 29 per cent of women have high blood pressure or are being treated for the condition.

The Bristol Heart Institute

The Bristol Heart Institute is made up of over 200 researchers and clinicians, from eight different departments in the University of Bristol, spanning three faculties, and from associated Bristol NHS Trusts. Research income is generated from grants, with the British Heart Foundation being the Institute’s main funder. As well as improving collaboration between scientists and clinicians within the Institute, the aim is to communicate research findings to the public.