The programme received funding from the sLoLa (strategic Longer and Larger grant) scheme, which supports teams in pursuing ambitious, multidisciplinary team-based bioscience research.
The programme, funded for 60 months, is a collaboration between Professor James Hodge (University of Bristol), Dr Mino Belle (University of Manchester), Dr Marco Brancaccio (Imperial College London), Professor Hugh Piggins (University of Bristol), Professor Krasi Tsanova-Atananova (University of Exeter), and Dr Alessio Vagnoni (King's College London).
The CircadiAgeing project explores how disruptions in circadian rhythms, the natural 24-hour cycles of physiological and behavioural patterns, contribute to ageing and related health issues.
Focusing on both the well-known molecular clock and the less understood membrane-based mechanisms that mediate daily changes in cell excitability, this crucial project aims to uncover how these clocks weaken synergistically with age, impacting our overall health.
Using interdisciplinary methods including cutting-edge genetic analysis and computational biology, the research team hopes to develop interventions that could restore the robustness of these biological clocks, promoting healthier ageing and potentially reducing age-related disorders.