Hosted by the School of Biochemistry

ABSTRACT: Here, I would discuss how we decipher the molecular mechanisms underpinning membrane protein function using the emerging hydrogen deuterium exchange-mass spectrometry (HDX-MS) technology. Our group has recently established the study of lipid-mediated conformational dynamics in membrane transporters. Currently our interests lie in exploring how the lipid environment and pharmacologically important ligands shape the conformational landscape of membrane proteins and their complexes, including membrane transporters and G-protein coupled receptors, important for human health and disease.

Argyris Politis from the University of Manchester is a Biophysicist and Mass Spectrometrist  interested in membrane transporters and GPCRs, and how they relate to human health and disease.