A Snapshot seminar hosted by the School of Physiology, Pharmacology and Neuroscience
Host: James Hodge
Continuous long-term recordings (months to years) in patients with epilepsy directly show that seizures are regulated in a circadian manner in 80% of the cases. Besides, these recordings allowed to prove the presence of a much slower rhythm (days to weeks) of seizures. They strongly suggest the existence of specific molecular processes that influence the time of occurrence of seizures. I will show that cortical structures undergo dynamic reconfiguration of their molecular architecture in a daily manner in health and disease. Accounting for daily and multidien molecular rhythms is essential to our understanding of brain function and dysfunction.