Hosted by the Wellcome Neural Dynamics PhD Programme
Modulatory biological rhythms have long been associated with neurological conditions, and these associations are thought to be underpinned by bi-directional relationships. In human epilepsy, the exact mechanisms underpinning these relationships are largely unknown and may differ between individuals.
In my talk, I will review multiple aspects of this bi-directional relationship in terms of evidence from human epilepsy. Particularly, multiple aspects of epileptic seizures appear to be modulated by biological rhythms on ultradian, circadian, and infradian timescales. Similarly, interictal epileptiform activity is also known to be modulated by biological rhythms. This has spurred recent investigations into the temporal stability and short-term validity of classical biomarkers of the epileptogenic zone, such as spikes and HFOs. Finally, I will highlight how epilepsy as a condition, and brain pathology may in turn impact biological rhythms.
I will welcome discussions on how these biological rhythms may be studied and used in future to design chronotherapy and other novel treatment strategies in epilepsy and other disease conditions.
If joining online: https://bristol-ac-uk.zoom.us/j/94138286231?pwd=MlRURE1SWjR6OTZCR1Fnak9QbGxhUT09