Hosted by the School of Biochemistry
Secreted proteins fulfil a vast array of functions, including immunity, signalling and extracellular matric remodelling. In the trans-Golgi network, proteins destined for constitutive secretion are sorted into post-Golgi carriers which fuse with the plasma membrane. The molecular machinery involved is poorly understood. We use proteomics, CRISPR screens, biochemistry, super-resolution imaging and kinetic trafficking assays to dioscover and characterise novel machinery for the secretory pathway.
Free tea, coffee and biscuits following the talk.