Hosted by the School of Biochemistry

Host: Girish Ram Mali

Central nervous system cells are generated from a small number of heterogeneous populations of neural stem/progenitor cells (NSCs) that are specified into distinct cell fates. Intrinsic and extrinsic signaling cues govern mammalian NSCs fate specification and subsequent differentiation involving changes in chromatin architecture, epigenetic marks and transcription that determine fate commitment programs into a specific lineage.

Our experimental evidence provides an understanding on how Radial Glial cells, a neural stem/progenitor cell population, during development can give rise to different cell types during cortical development. I will report on how fate commitment decisions towards the ependymal lineage is determined and provide links of these findings to the pathogenetic mechanisms of hydrocephalus.

Below are a couple of his recent publications:

• Landskron L., Bak J., Adamopoulos A., Kaplani K., Moraiti M., Lisa G van den Hengel, Ji-Ying Song, Onno B Bleijerveld, Joppe Nieuwenhuis, Tatjana Heidebrecht, Linda Henneman, Marie-Jo Moutin, Marin Barisic, Taraviras S., Anastassis Perrakis, Thijn R Brummelkamp Posttranslational modification of microtubules by the MATCAP detyrosinase. Science. April 2022
• Karantzelis N, Petropoulos M, De Marco V, Egan DA, Fish A, Christodoulou E, Will DW, Lewis JD, Perrakis A, Lygerou Z and Taraviras S Small Molecule Inhibitor Targeting CDT1/Geminin Protein Complex Promotes DNA Damage and Cell Death in Cancer Cells, Frontiers in Pharmacology, April 2022 13:860682.