A Snapshot seminar hosted by the School of Physiology, Pharmacology and Neuroscience
Sensory perception and learning is thought to be associated with brain plasticity. Here we discover, using multiphoton imaging in awake mice, that a brief period of rhythmic whisker stimulation (RWS) induces a strong, long-lasting increase in whisker-evoked pyramidal neuron responses in the Barrel Cortex (BC) of S1. Previously, we have shown that this plasticity may be mediated VIP interneuron activated disinhibition. Therefore, separately we tested VIP interneuron activity during RWS. Altogether, this indicates the cortical representation of sensory input is dynamic and can be modulated over hours by repetitive sensory input, via mechanisms that may involve disinhibition.
Host: Shinjini Basu
Join via Zoom: https://bristol-ac-uk.zoom.us/j/4798119105?pwd=MlZRZEt6aWhQb0NYT2pXd3N5aVRvQT09