Hosted by the School of Cellular and Molecular Medicine

Abstract: E. coli and K. pneumoniae are major pathogenic bacteria responsible a wide range of infections. In both E. coli and K. pneumoniae, infections and antibiotic resistance is linked to successful high-risk clones. Colonization, predominantly in the gastrointestinal tract, has been suggested to be a key factor for success and considered a platform from which antibiotic resistance is launched into various trajectories. Both E. coli and K. pneumoniae are commensal colonizers of the human gastrointestinal tract and genomic studies confirm that patients’ gut colonization is significantly associated with subsequent infection. Antibiotic use is a well-known factor disrupting the microbiota, facilitating colonization and selecting for antibiotic resistance. However, a growing body of evidence suggests that a large variety of non-antibiotic drugs also influence the microbiota composition and display broad antibacterial activity. In this talk I will present recent data from our large-scale longitudinal nationwide cohort studies, population-based carriage studies and selection of resistance by non-antibiotic drugs.

Institutional Profile: Samuelsen, Ørjan | UiT

A 'Tea with the Speaker' will follow this seminar, where Pathway 2/PGR staff and students are warmly encouraged to join in an informal discussion with the speaker following their talk. 

Host: Professor Jim Spencer 

Zoom Webinar Link: https://bristol-ac-uk.zoom.us/j/92544534019  

Tea with the Speaker Zoom Link: https://bristol-ac-uk.zoom.us/j/98639671363?pwd=NXhDUGxuSXhOTloreFhpRmkydzBOUT09
Passcode: 512149