Signalling with ubiquitin—communication between metabolism, immune responses and DNA damage repair

7 November 2019, 1.00 PM - 7 November 2019, 2.00 PM

Elton Zeqiraj (University of Leeds)

C42, Biomedical Sciences Building

A School of Biochemistry seminar, hosted by Imre Berger 

Elton is a Sir Henry Dale fellow interested in ubiquitin structural biology with a main focus on deubiquitinating enzymes (a.k.a. DUBs). The majority of his efforts are dedicated towards understanding how DUBs are activated allosterically, and how they can be inhibited when it is beneficial to do so.

If you would like to meet with Elton during his visit, please contact Imre Berger (imre.berger@bristol.ac.uk)

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Selected publications:

Walden M, Tian L, Ross RL, Sykora UM, Byrne DP, Hesketh EL, Masandi SK, Cassel
J, George R, Ault JR, El Oualid F, Pawłowski K, Salvino JM, Eyers PA, Ranson NA,
Del Galdo F, Greenberg RA, Zeqiraj E.
Metabolic control of BRISC-SHMT2 assembly regulates immune signalling. Nature. 2019
doi:10.1038/s41586-019-1232-1.

Walden M, Masandi SK, Pawłowski K, Zeqiraj E.
Pseudo-DUBs as allosteric activators and molecular scaffolds of protein complexes. Biochem Soc Trans. 2018
doi: 10.1042/BST20160268.

Zeqiraj E, Tian L, Piggott CA, Pillon MC, Duffy NM, Ceccarelli DF, Keszei AF,
Lorenzen K, Kurinov I, Orlicky S, Gish GD, Heck AJ, Guarné A, Greenberg RA,
Sicheri F.
Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function. Mol Cell. 2015 doi:10.1016/j.molcel.2015.07.028.

Zeqiraj E, Tang X, Hunter RW, García-Rocha M, Judd A, Deak M, von
Wilamowitz-Moellendorff A, Kurinov I, Guinovart JJ, Tyers M, Sakamoto K, Sicheri F.
Structural basis for the recruitment of glycogen synthase by glycogenin. Proc Natl Acad Sci U S A. 2014
doi: 10.1073/pnas.1402926111.

Contact information

For further information contact bioc-seminars@bristol.ac.uk

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