The ATLANTIS trial, led by researchers at the Universities of Bristol, Southampton, and Leeds, and published in The Lancet, was funded by the National Institute for Health and Care Research (NIHR).
The RCGP Research Paper of the Year Award will be presented at the annual RCGP Conference today [3 October]. The award recognises and celebrates an individual or group of researchers who have undertaken and published an exceptional piece of research relating to general practice or primary care.
The ATLANTIS trial showed that people with IBS taking low dose amitriptyline were almost twice as likely to report an overall improvement in their IBS symptoms to those taking a placebo. Amitriptyline, already prescribed at low dose for a range of other health conditions, was also more acceptable to participants than placebo and performed better across a wide range of IBS symptom measures.
The ATLANTIS results are widely applicable to the majority people with IBS as most have their condition managed in primary care by their GP.