Adult hospitalisations from Omicron-related SARS-CoV-2 (COVID-19) were less severe than Delta and the Pfizer-BioNTech vaccine (also known as Comirnaty and BNT162b2*) remains effective in preventing not only hospitalisation, but severe patient outcomes associated with COVID-19, two new research studies have found.
Scientists have created a much faster way to make certain complex molecules, which are widely used by pharmaceuticals for antibiotics and anti-fungal medicines.
Scientists have discovered why some coronaviruses are more likely to cause severe disease, which has remained a mystery, until now. Researchers of the University of Bristol-led study, published in Science Advances today [23 November], say their findings could lead to the development of a pan-coronavirus treatment to defeat all coronaviruses—from the 2002 SARS-CoV outbreak to Omicron, the current variant of SARS-CoV-2, as well as dangerous variants that may emerge in future.
A new randomised controlled clinical trial, led by the University of Bristol, will investigate whether rapid microbiological 'point-of-care' tests for respiratory infections could reduce antibiotic prescribing in primary care, thanks to funding of £1.6 million by the National Institute for Health and Care Research (NIHR). The tests, which are carried out in GP surgeries rather than sent to a laboratory, detect the presence of viruses and some bacteria, with results available on the same day.
Each year the University of Bristol picks six outstanding theses – one from each faculty – from hundreds of fascinating submissions by doctoral researchers in the last year. This year’s winners each receive £500 and a special certificate.
University of Bristol academics, Drs Ellen Brooks Pollock OBE, Leon Danon, Robert Challen, Amy Thomas and Emily Nixon have been recognised for their epidemiological modelling work supporting the UK government’s response to the coronavirus pandemic.
Red blood cells that have been grown in a laboratory have now been transfused into another person in a world first clinical trial led by a UK team including University of Bristol researchers.
Climate change is one of the biggest health threats facing humanity. It is already affecting our health, and these impacts are likely to increase. A series of short films developed by the University of Bristol’s Elizabeth Blackwell Institute for Health Research and Cabot Institute for the Environment explain how the health of our planet is linked to human health, and how research at Bristol will help us to understand these complex and interwoven issues.
The National Institute for Health and Care Research (NIHR) is funding a definitive follow-on trial to TEST (Trial of Eczema allergy Screening Tests), which investigated the feasibility of evaluating the use of routine food allergy tests for the control of childhood eczema.
Academics from the University of Bristol have been awarded prestigious Philip Leverhulme Prizes.
GP practices and NHS Trusts across the West of England will play a vital role in a new respiratory virus study looking into the leading cause of infant hospitalisation.
People at risk of heart disease are more likely to be prescribed relevant medications if they see the same GP over time (known as continuity of care) but not more likely to take their medications (known as adherence), according to researchers at the University of Bristol.
Scientists from the University of Bristol and NHS Blood & Transplant (NHSBT) have discovered a rare new blood group system. The findings, published in Blood, the journal of the American Society of Hematology, also solve a 30-year mystery.
Dr Cher Farrugia, a dentist and researcher at the University of Bristol Dental School, has been awarded the prestigious British Society of Oral and Dental Research (BSODR) President's Prize for her research in translational microbiology.
COVID-19 infection increases the risk of potentially life-threatening blood clots for at least 49 weeks, according to a new study of health records of 48 million unvaccinated adults from the first wave of the pandemic.
Two University of Bristol academics have been conferred as Fellows of the Academy of Social Sciences.
An increase in the number of non-COVID-19 respiratory infections should be expected this winter, say scientists. The warning comes following the results of a new study, published in The Lancet Regional Health – Europe, which found that over 55% of respiratory disease hospitalisations during the pandemic’s peak were caused by non-SARS-CoV-2 infections.
Genetic mutations which cause a debilitating hereditary kidney disease affecting children and young adults have been fixed in patient-derived kidney cells using a potentially game-changing DNA repair-kit. The advance, developed by University of Bristol scientists, is published in Nucleic Acids Research.
New research has revealed an association between the feeding of raw meat to pet dogs and the presence of bacteria resistant to critically important antibiotics.
Two new animations from the NIHR Biomedical Research Centre (BRC) report the views and experiences of young people (from 8 to 17 years old) using flash monitoring for type 1 diabetes.
Protection against severe COVID-19 by two doses of Pfizer-BioNTech and AstraZeneca COVID-19 vaccines remained high up to six months after second doses, finds new research which analysed NHS health record data on over seven million adults. Reassuringly, the University of Bristol-led study published in The BMJ today [July 20], found protection in older adults aged over 65 years, and in clinically vulnerable adults.
New evidence has found a link between poor health as a newborn and mortality up to the age of ten. The new report from England’s National Child Mortality Database (NCMD), led by the University of Bristol, shows of the 4,829 children aged ten and under who died in England between 2019 and 2021, 72 per cent were found to have required additional care in the neonatal period.
New research has found people from lower socioeconomic backgrounds who regularly exercise could substantially reduce their risk of chronic kidney disease. Chronic kidney disease is linked to poor quality of life and an increased risk of death. Its treatment is also associated with high healthcare costs, with diabetes and high blood pressure major factors that contribute to the disease.
Bristol-based study Children of the 90s has helped improve understanding of the causes and treatment of long COVID.
Some public venues may need better ventilation to prevent the spread of COVID-19 following growing evidence of the potential for 'long distance' airborne transmission of the disease, suggests research published by The BMJ today [29 June].
More than 650,000 babies are born every year in the UK, and during the pandemic some of them will have been exposed to SARS-CoV-2, the coronavirus which causes COVID-19. A national study, funded by the charity Action Medical Research, will investigate the long-term impact of exposure to SARS-CoV-2 in the womb or shortly after birth.
The SARS-CoV-2 virus can lose 90% of infectivity when in aerosol particles within 20 minutes, according to new University of Bristol findings. The study, published in the journal of the Proceedings of the National Academy of Sciences (PNAS), is the first to investigate the decrease in infectivity of SARS-CoV-2 in aerosol particles over periods from seconds to a few minutes. The aim of the study was to explore the process that could change viral infectivity over short timescales following exhalation.
The University of Bristol is launching Bristol Innovations, a new initiative that will combine its far-reaching research expertise with the industry know-how of global partners, leading to progressive sector-wide and multidisciplinary discoveries.
The University of Bristol's Infection and Immunity Network, supported by the Elizabeth Blackwell Institute, hosted its 11th annual symposium in the Geographical Sciences Building on 21 June 2022. Jointly hosted with the Bristol Vaccine Centre, the event presented a narrative of the vaccine pathway, from initial cellular work through to delivery in communities.
Four Bristol academics and 80 other promising science and research leaders will receive £97.8 million to conquer major global issues and commercialise their innovations in the UK.
An international team of scientists, led by the University of Bristol, has been investigating how the SARS-CoV-2 virus, the coronavirus responsible for the COVID-19 pandemic, manipulates host proteins to penetrate into human cells. After identifying Neuropilin-1 (NRP1) as a host factor for SARS-CoV-2 infection, new findings published in the journal of the Proceedings of the National Academy of Sciences (PNAS) today [14 June] describe how the coronavirus subverts a host cell pathway in order to infect human cells.
A major community-powered project in Bristol is set to launch an outreach programme to address HIV stigma and increase testing among people of African and Caribbean heritage.
Bacterial sampling is now underway to assess the abundance and types of antimicrobial resistance (AMR) in bacteria on Welsh dairy, beef and sheep farms.
The Best Emollients for Eczema trial has found that no one type of moisturiser is better than another. This study, the first in the world to directly compare different types of moisturisers, highlights the importance of patient education and choice when deciding which moisturisers to use for children with eczema. The results from the National Institute for Health and Care Research (NIHR) funded study are published in The Lancet Child & Adolescent Health and British Journal of General Practice today [24 May].
Using inhaled antibiotics to treat lower respiratory tract infections could help reduce antimicrobial resistance, according to researchers from the University of Bristol and University of Bath.
Imre Berger, Professor of Biochemistry and Chemistry and Director of Bristol’s Max Planck Centre for Minimal Biology has been elected as a Fellow of the Academy of Medical Sciences for his outstanding contributions to biomedical science and notable discoveries during the COVID-19 pandemic.
A study that explored the attitudes of vaccine hesitant adults in the UK towards uptake of the COVID-19 vaccine found that participants were hesitant rather than opposed to the vaccine. They had questions about their need for, and the safety and efficacy of the vaccine. Concerns were exacerbated by a lack of trust in government and misunderstanding of science, the University of Bristol-led study found.
Genetic studies aim to find regions of the genome that associate with diseases or other outcomes. A new study has shown that for social traits these genetic effects are due to a mixture of direct effects (e.g. biological effects of DNA), and indirect effects (e.g. family or social environment). Whereas biological traits are mainly driven by direct effects.
Being overweight in childhood increases the risk of developing type 1 diabetes in later life, according to the findings of a new study that analysed genetic data on over 400,000 individuals. The study, co-led by researchers from the Universities of Bristol and Oxford and published today in Nature Communications, also provides evidence that being overweight over many years from childhood influences the risk of other diseases including asthma, eczema and hypothyroidism.
Cardiac surgery patients may experience different levels of disruption to their body producing life-saving hormones during their operations, a new study reveals.
