Prof Allon Hochbaum (University of California, Irvine)

27 March 2025, 1.00 PM - 27 March 2025, 2.00 PM

C42 Biomedical Sciences Building, University of Bristol

Allon Hochbaum is an Associate Professor in the Departments of Materials Science and Engineering, Chemistry, Chemical and Biomolecular Engineering, and Molecular Biology and Biochemistry at the University of California, Irvine. 

Title: Natural and Synthetic Conductive Proteins: from Rock-Breathing Bacteria to Electrocatalytic Materials

Abstract: Electronic signals are the default carriers of information in solid-state devices, while biology mainly traffics in chemical and ionic signals. Materials that can transduce biological and electronic signals are key to bridging living systems with synthetic devices such as soft robotics, therapeutic and prosthetic implants, bioenergy technologies, and wearable sensors. Ideal materials should mimic not only the soft mechanics and biomolecularly defined interfaces of cells and tissue, but also the dynamic nature of biological systems in response to stimuli. This talk will cover our progress in understanding the structural basis for conductivity in natural and synthetic protein wires, and the development of sequence-encoded designs for stimuli-responsive behavior:

(1) Nature has evolved protein assemblies that conduct electronic charge over nanometer to centimeter distances as part of an anaerobic respiratory metabolic pathway called extracellular electron transfer. Our findings show that such assemblies in the model anaerobe, Geobacter sulfurreducens, are fibers made of cytochrome (heme-containing protein) polymers that array heme in one-dimensional chains along the fiber axes. This alignment of redox active heme supports long-range electron transport along the nanowires to facilitate oxidation of remote electron acceptors. Our work seeks to understand structural determinants of their biochemical and electron transport properties.

(2) We design heme-free and heme-binding peptides (short proteins) that self-assemble into conducting filaments and mimic the environmental responsiveness of other biological filaments. To address this challenge, we developed a platform for the programmable assembly of de novo peptides by balancing order and disorder inducing peptide sequence motif. This approach provides control over the hierarchical assembly of complex supramolecular peptide nanostructures. The gating of supramolecular interactions in response to pH, redox, and biochemical stimuli represent key advances towards the interconversion of biological signals across bionic interfaces and the integration of synthetic biology with a synthetic materials toolkit.

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Allon Hochbaum received his S.B. in Materials Science and Engineering from the Massachusetts Institute of Technology and completed his Ph.D. in the Department of Chemistry at UC Berkeley studying electrical and thermal transport phenomena in semiconductor nanowires. He was a postdoctoral research fellow at Harvard University where his research explored bacterial community dynamics at interfaces. Prof. Hochbaum is the recipient of the 3M Non-Tenured Faculty award, and the ACS (Division of Inorganic Chemistry) and AFOSR Young Investigator awards. His lab studies and designs electronically conductive natural and synthetic supramolecular proteins, and seeks to measure and understand stress responses in bacteria for the development of new diagnostic tools and antimicrobial therapies.

 

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