The Wolfson Bioimaging Facility underpins international-quality research across the University of Bristol and further afield.
By providing a broad range of advanced imaging technologies encompassing and linking light and electron microscopy, the Facility supports many research areas, including:
- Cardiovascular Science
- Cell Biology
- Infection and Immunity
- Synthetic Biology
Our user base currently encompasses over 300 researchers from a wide range of disciplines in the biomedical and physical sciences across the University. The impact and scope of the Wolfson Bioimaging Facility is seen in over 700 research publications that include data acquired on our microscopes.
We advise and train researchers at all levels of their careers to optimise the use of our microscope systems and to process and analyse the data they generate.
Recent publications highlights
- Engineered synthetic scaffolds for organizing proteins within the bacterial cytoplasm. Nature Chemical Biology doi: 10.1038/nchembio.2535 (2017)
- A transient pool of nuclear F-actin at mitotic exit controls chromatin organization. Nature Cell Biology doi: 10.1038/ncb3641 (2017)
- Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling. Nature Cell Biology 19:1214-1225 (2017)
- Higher-order assembly of crystalline cylindrical micelles into membrane-extendable colloidosomes. Nature Communications 8:426. (2017)
- PICK1 regulates AMPA receptor endocytosis via direct interactions with AP2 α-appendage and dynamin. Journal of Cell Biology 216: 3323-3338. (2017)
- Sequence-dependent cargo recognition by SNX-BARs mediates retromer-independent transport of CI-MPR. Journal of Cell Biology 216: 3695-3712. (2017)
- Metabotropic action of postsynaptic kainate receptors triggers hippocampal long-term potentiation. Nature Neuroscience 20: 529-539 (2017)
- Decorating self-assembled peptide cages with proteins. ACS Nano 11:7901-7914. (2017)
- Predatory behaviour in synthetic protocell communities. Nature Chemistry 9, 110-119 (2017) .
- Interleukin-33 regulates tissue remodelling and inhibits angiogenesis in the eye. Journal of Pathology 241: 45-56 (2017)
- Two-dimensional assemblies from crystallizable homopolymers with charged termini. Nature Materials 16: 481-488 (2017)
- PKCθ links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton. Elife 6. pii: e20003. (2017)
- Assembly, secretory pathway trafficking and surface delivery of kainite receptors is regulated by neuronal activity. Cell Reports 19: 2613-26 (2017)
- Purinergic receptors in the carotid body as a new drug target for controlling hypertension. Nature Medicine 22:1151-1159 (2016).
- Photonic multilayer structure of Begonia chloroplasts enhances photosynthetic efficiency. Nature Plants 2:16162 (2016).
- Spontaneous assembly of chemically encoded two-dimensional coacervate droplet arrays by acoustic wave patterning Nature Communications 7:13068 (2016).
- Corpse engulfment generates a molecular memory that primes the macrophage inflammatory response. Cell 165: 1658-71 (2016).
- Uniform patchy and hollow rectangular platelet micelles from crystallizable polymer blends. Science 352: 697-701 (2016)
- Efficient, non-toxic anion transport by synthetic carriers in cells and epithelia. Nature Chemistry: 24-32 (2016)
- Systems analysis of the dynamic inflammatory response to tissue damage reveals spatiotemporal properties of the wound attractant gradient. Current Biology 26: 1975-89 (2016).
Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling. Nature Cell Biology 19:1214-1225 (2017)
Higher-order assembly of crystalline cylindrical micelles into membrane-extendable colloidosomes. Nature Communications 8:426. (2017)
PICK1 regulates AMPA receptor endocytosis via direct interactions with AP2 α-appendage and dynamin. Journal of Cell Biology 216: 3323-3338. (2017)