The Wolfson Bioimaging Facility underpins international-quality research across the University of Bristol and further afield.
By providing a broad range of advanced imaging technologies encompassing and linking light and electron microscopy, the Facility supports many research areas, including:
- Cardiovascular Science
- Cell Biology
- Infection and Immunity
- Synthetic Biology
Our user base currently encompasses over 350 researchers from a wide range of disciplines in the biomedical and physical sciences across the University. The impact and scope of the Wolfson Bioimaging Facility is seen in over 800 research publications that include data acquired on our microscopes.
We advise and train researchers at all levels of their careers to optimise the use of our microscope systems and to process and analyse the data they generate.
Recent publication highlights
- A floating mold technique for the programmed assembly of protocells into protocellular materials capable of non-equilibrium biochemical sensing. Advanced Materials May7:e2100340 (2021)
- Proteotoxic stress is a driver of the loser status and cell competition. Nature Cell Biology 23:136-146 (2021)
- Giantin is required for intracellular N-terminal processing of type I procollagen. Journal of Cell Biology 220:e202005166 (2021)
- Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science 370: 861-865 (2020)
- Tailored self-assembled photocatalytic nanofibers for visible-light-driven hydrogen production. Nature Chemistry 12: 1150-1156 (2020)
- Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein. Science 370: 725-730 (2020)
- In situ cryo-electron tomography reveals filamentous actin within the microtubule lumen. Journal of Cell Biology 219 (9): e201911154 (2020)
- De novo designed peptide and protein hairpins self-assemble into sheets and nanoparticles. Small https://doi.org/10.1002/smll.202100472
- A role for NPY-NPY2R signaling in albuminuric kidney disease. Proc. Natl. Acad. Sci. USA 117: 15862-15873 (2020)
- Minding the gap between plant and bacterial photosynthesis within a self-assembling biohybrid photosystem. ACS Nano 14: 4536-4549 (2020)
- RhoJ regulates α5β1 integrin trafficking to control fibronectin remodeling during angiogenesis. Current Biology 30: 2146-2155 (2020)
- Cellular uptake and targeting of low dispersity, dual emissive, segmented block copolymer nanofibers. Chemical Science https://doi.org/10.1039/D0SC02593C (2020)
- A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons. Autophagy doi: 10.1080/15548627.2020.1739441 (2020)
- Antibacterial effects of nanopillar surfaces are mediated by cell impedance, penetration and induction of oxidative stress. Nature Communications 11: 1626 (2020)
- Hydrogel-immobilized coacervate droplets as modular micro-reactor assemblies. Angew Chem Int Ed Engl. doi: 10.1002/anie.201916481 (2020)
- The human HELLS chromatin remodelling protein promotes end resection to facilitate homologous recombination and contributes to DSB repair within heterochromatin. Nucleic Acids Research 14: 1872-1885 (2020).
- Catalytic processing in ruthenium-based polyoxometalate coacervate protocells. Nature Communications 11:41 (2020)
Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science 370: 861-865 (2020)
Tailored self-assembled photocatalytic nanofibers for visible-light-driven hydrogen production. Nature Chemistry 12: 1150-1156 (2020)
Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein. Science 370: 725-730 (2020)