Neuropilin-1 drives SARS-CoV-2 infectivity, finds breakthrough study20 October 2020In a major breakthrough an international team of scientists, led by the University of Bristol, has potentially identified what makes SARS-CoV-2 highly infectious and able to spread rapidly in human cells. The findings, published in Science today [20 October] describe how the virus’s ability to infect human cells can be reduced by inhibitors that block a newly discovered interaction between virus and host, demonstrating a potential anti-viral treatment.
Discovery of a druggable pocket in the SARS-CoV-2 Spike protein could stop virus in its tracks21 September 2020A druggable pocket in the SARS-CoV-2 Spike protein that could be used to stop the virus from infecting human cells has been discovered by an international team of scientists led by the University of Bristol. The researchers say their findings, published today [21 September] in the journal Science, are a potential 'game changer' in defeating the current pandemic and add that small molecule anti-viral drugs developed to target the pocket they discovered could help eliminate COVID-19.
New drug formulation could treat Candida infections28 April 2020With antimicrobial resistance (AMR) increasing around the world, new research led by the University of Bristol has shown a new drug formulation could possibly be used in antifungal treatments against Candida infections.
Catalytic protocells get zingy8 January 2020Artificial cells capable of oxygen gas production and chemical signalling have been prepared using a combination of synthetic and biological catalysts through an international collaboration between the University of Bristol and the University of Padua in Italy.
Scientists discover body’s protection shield18 November 2019Scientists have discovered a way to manipulate the body’s own immune response to help boost tissue repair. The findings, published in Current Biology today [18 Nov], reveal a new network of protective factors to shield cells against damage. This discovery, made by University of Bristol researchers, could significantly benefit patients undergoing surgery by speeding recovery times and lowering the risk of complication
Powerful new synthetic vaccines to combat epidemics25 September 2019A new type of vaccine that can be stored at warmer temperatures, removing the need for refrigeration, has been developed for mosquito-borne virus Chikungunya in a major advance in vaccine technology. The findings, published in Science Advances today [Wednesday 25 September], reveal exceptionally promising results for the Chikungunya vaccine candidate, which has been engineered using a synthetic protein scaffold that could revolutionise the way vaccines are designed, produced and stored.
Putting the squeeze on red blood cells11 September 2019For the first time, researchers at the University of Bristol’s Blood and Transplant Research Unit, and the French National Institute for Blood Transfusion, have captured the moment a red blood cell is ‘squeezed’ while recording the changes that allow it to deform and subsequently recover its shape.