Dynamic Molecular Cell Biology (Wellcome Trust)

Find a programme
Run by Faculty of Life Sciences
Awards available PhD
Programme length Four years full-time
Location of programme Clifton campus
Part-time study available No, full-time only
Start date September 2020

Programme overview

This programme brings together the skills and expertise of more than 30 internationally recognised molecular cell biologists who provide training in a broad range of cell biology topics and techniques; from analysing dynamic behaviour of cells in organisms to studies of intracellular behaviour and now progression into single molecules and high-resolution electron microscopy. Training also covers the spectrum from the purest studies of fundamental cell biology through to direct and translational applications to human disease.

We are looking for talented and motivated students who are willing to take up the many varied challenges in cell biology and are open to learning about new disciplines and working across different fields.

Visit the Dynamic Molecular Cell Biology web pages to read profiles of current students and find out more about the programme.

Fees for 2020/21

We charge an annual tuition fee. Fees for 2020/21 are as follows:

UK/EU: full-time
£4,365
Overseas: full-time
£23,200
Channel Islands/Isle of Man: full-time
£9,365

Bench fees: For postgraduate research students who are not funded by UK Research Councils or (specific) UK charities, it is usual to charge a bench fee. A bench fee covers the costs of laboratory consumables, specialist equipment and other relevant costs (e.g. training) for the duration of the programme. The bench fee charged can vary considerably depending on the nature of the programme being undertaken. Details of specific bench fee charges can be provided on request and will made clear in the offer letter sent to applicants.

Fees are subject to an annual review. For programmes that last longer than one year, please budget for up to a five per cent increase in fees each year. Find out more about tuition fees.

Alumni scholarship

University of Bristol students and graduates can benefit from a ten per cent reduction in tuition fees for postgraduate study. Check your eligibility for an alumni scholarship.

Funding for 2020/21

This programme is fully funded by the Wellcome Trust. The trust provides funding to cover PhD programme fees at UK/EU student rate, research expenses, a stipend for living expenses, contribution towards travel and a contribution towards transferable-skills training. International students are welcome to apply.

Further information on funding for prospective UK, EU and international postgraduate students.

Programme structure

First year

You will have the opportunity to study a range of research topics with different supervisors and undertake three 10-week lab-based research projects.

Your first rotation will be in a cellular lab, where you'll gain experience in cell culture and standard wide-field/confocal cell imaging alongside super-resolution imaging.

Your second rotation will be in a disease/model organism lab to extend your skills into in vivo applied context and in techniques such as multiphoton imaging.

Finally, your third rotation will be in a molecular lab enabling you to become familiar with in vitro biochemical and biophysical methods, including protein production, complex assembly, functional reconstitution, high-resolution electron microscopy and single molecular imaging.

Write-ups, posters and presentations on the three rotation projects are completed by the end of June, providing you with three months in which to select your full PhD laboratory and focus on your proposed research project before the second year starts.

Second to fourth years

You will join a single laboratory for the remaining years of your PhD. On occasions there may be collaborative projects between two participating labs.

After your first year, you will be integrated into the PhD programme of your host school, which will depend on your chosen topic. These school programmes are similar to one another but not identical. In general, they involve submission of an end-of-year progress report to the departmental postgraduate tutor and an afternoon of seminars presented by your year cohort in that school, and subsequently an informal interview/viva with the postgraduate tutor or another senior academic. You will also remain under the wing of the Dynamic Molecular Cell Biology programme itself, which has its own monitoring procedure.

Entry requirements

A first or upper second-class honours degree or master's degree in a biomedical or life science discipline.

See international equivalent qualifications on the International Office website.

English language requirements

If English is not your first language, you need to meet this profile level:
Profile C
Further information about English language requirements and profile levels.

Admissions statement

Read the programme admissions statement for important information on entry requirements, the application process and supporting documents required.

Admissions statement

Research groups

Core research areas are:

  • multiprotein complexes in gene maintenance and expression;
  • dynamic organisation, regulation and re-modelling of the cytoskeleton;
  • molecular complexes involved in protein translocation and trafficking;
  • cell organisation, morphogenesis and tissue function;
  • cancer, neuroscience, infection and immunity, cardiovascular biology.

Group leaders:

  • Cellular
    • Professor Peter Cullen
    • Professor Jo Adams
    • Dr Jon Hanley
    • Professor Jeremy Henley
    • Dr Jon Lane
    • Professor Harry Mellor
    • Dr Binyam Mogessie
    • Professor Catherine Nobes
    • Professor David Stephens
    • Professor Paul Verkade
  • Molecular
    • Professor Ian Collinson
    • Professor Imre Berger
    • Professor Christiane Berger-Schaffitzel
    • Professor Rafael Carazo Salas
    • Professor Mark Dillingham
    • Dr Mark Dodding
    • Professor Stefan Roberts
    • Professor Nigel Savery
    • Professor Mark Szczelkun
  • Disease/model organism
    • Professor Paul Martin
    • Dr Borko Amulic
    • Dr Anna Chambers
    • Dr Abdu Essafi
    • Dr Chrissy Hammond
    • Professor Patty Kuwabara
    • Dr Stuart Mundell
    • Dr Eugenia Piddini
    • Professor Alastair Poole
    • Professor Anne Ridley
    • Dr Beck Richardson
    • Dr Ash Toye
    • Dr Helen Weavers
    • Professor Ann Williams
    • Professor Christoph Wuelfing
    • Dr Yohei Yamauchi

Careers

The vast majority of graduates go on to perform post-doctoral research in world-leading laboratories in the UK, Europe and the US. Some students have taken graduate-level entry to study medicine or entered teacher training programmes.

Staff profiles

Cellular

Professor Jo Adams MA (Cantab.), PhD (Lond.), (Professor of Cell Biology), Role of Signaling to the Cytoskeleton by the Extracellular Matrix in Cell Motility Processes

Professor Peter Cullen BSc, PhD (E.Anglia), (Professor of Biochemistry / Royal Society Wolfson Research Merit Award Holder), Endosomal sorting and signaling

Dr Jon Hanley BA (Cantab.), PhD (U.C.Lond.), (Reader in Molecular Neuroscience), The molecular mechanisms of synaptic plasticity

Professor Jeremy Henley BSc (Aston), PhD (Lond.), (Professor of Molecular Neuroscience), Neurotransmitter receptor trafficking in plasticity and disease

Dr Jon Lane BSc (Soton.), PhD (Exon.), (Reader in Cell Biology), Molecular regulation of autophagy

Professor Harry Mellor BSc (Edin.), PhD (Bristol), (Professor of Biochemistry), Endothelial cell dynamics in angiogenesis

Dr Binyam Mogessie PhD, BSc, (Sir Henry Dale Research Fellow)

Professor Catherine Nobes BSc, PhD (Lond.), (Professor of Cell Biology / Head of School), Regulation of cell migration and cancer cell invasion by Eph receptors and ephrins

Professor David Stephens BSc, PhD (Lond.), (Professor of Cell Biology), Membrane and cytoskeleton dynamics in health and disease.

Professor Paul Verkade MSc, PhD (Utrecht), (Professor of Bioimaging), Visualising of protein trafficking/translocation events.

Disease/Model organism

Dr Borko Amulic, (Lecturer in Immunology), Neutrophil NETosis

Dr Anna Chambers MBiochem (Oxon.), PhD (Bristol), (CRUK Career Development Fellow), Chromatin remodelling and genome stability

Dr Abdu Essafi BSc (Lond.), PhD (Lond.), (Lecturer), Molecular basis of embryonic processes in health and disease

Dr Chrissy Hammond MBiochem (Oxon.), PhD (Lond.), (Senior Research Fellow), Modelling osteoarthritis in zebrafish: looking at cell ' decision making' in the joint

Professor Patty Kuwabara BA (Johns Hopkins), PhD (Penn.), (William P. Coldrick Chair in Genomics)

Professor Paul Martin BSc (Sus.), PhD (Lond.), (Professor of Cell Biology), Inflammation in repair and cancer

Dr Stuart Mundell BSc (Glas.), PhD (Bristol), (Professor in Cellular Pharmacology), G protein-coupled receptor function and signalling in atherothrombosis

Dr Eugenia Piddini PhD, BSc, MSc, (Professorial Research Fellow in Cell Biology), Cell competition in normal physiology and cancer

Professor Alastair Poole Vet.M.B., MA, PhD (Cantab.), M.R.C.V.S., (Professor of Pharmacology and Cell Biology), Platelet Cell Biology

Dr Beck Richardson BSc (UMIST), MPhil (Manch.), PhD (Manch.), (BHF Intermediate Research Fellow), The role of inflammatory cell signalling in tissue repair

Professor Anne Ridley BA Hons (Cantab.), PhD (London), (Professor / Head of School)

Dr Ash Toye BSc, PhD (Bristol), (Reader in Cell Biology), Red blood cell development in health and disease.

Dr Helen Weavers PhD (Cantab.), (Research Fellow), Cell resilience in repair and development

Professor Ann Williams BSc, PhD (Bristol), (Professor of Experimental Oncology), Colorectal tumour cell survival mechanisms and chemoprevention

Professor Christoph Wuelfing Dip (Munich), PhD (Munich), (Professor of Immunology), The spatiotemporal organization of lymphocyte signalling as a regulator of function

Dr Yohei Yamauchi, (Reader in Viral Cell Biology)

Molecular

Professor Imre Berger MSc (Hannover, Germany), PhD (Cambridge, USA and Hannover, Germany), HDR (ETH Zurich, Switzerland), (Professor of Biochemistry)

Professor Christiane Berger-Schaffitzel MSc (Hannover), PhD (Zurich), Habiliation (E.T.H.Zurich), (Professor of Biochemistry), Ribosomal complexes in protein targeting, translocation and quality control

Professor Rafael Carazo Salas PhD (Paris VII), DEA/MSc (Paris VII), CAS/MSc (Cantab.), BSc (Concordia), (Chair in Biomedical Sciences), Integrative cell biology of pluripotency and differentiation

Professor Ian Collinson BSc (Warw.), PhD (Cantab.), (Professor of Biochemistry), Understanding the mechanism of protein secretion and mitochondrial import

Professor Mark Dillingham BSc (Bristol), PhD (Oxon.), (Professor of Biochemistry), Helicases as modular components of DNA processing machines

Dr Mark Dodding BSc, PhD, (Senior Lecturer in Cell Biology)

Professor Stefan Roberts PhD (Sheff.), BSc (Sheff.), (Professor of Cancer Biology), Mechanisms of transcriptional regulation in mammalian cells

Professor Nigel Savery BSc, PhD (Birm.), (Professor of Biochemistry)

Professor Mark Szczelkun BSc (Liv.), PhD (Soton), (Professor of Biochemistry), Molecular mechanisms of genome processing and maintenance

How to apply
Application deadline:

5 January 2020

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REF 2014 results

  • Biological Sciences:
  • 33% of research is world-leading (4*)
  • 51% of research is internationally excellent (3*)
  • 15% of research is recognised internationally (2*)
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Results are from the most recent UK-wide assessment of research quality, conducted by HEFCE. More about REF 2014 results.

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Faculty Education Team Postgraduate Administrator Phone: +44 (0) 117 331 1534 Email: fls-pg-admissions@bristol.ac.uk

Faculty of Life Sciences
65 St Michael's Hill
Bristol
BS2 8DZ http://www.bristol.ac.uk/life-sciences/study/postgraduate/dynamic-cell/

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