Dynamic Molecular Cell Biology (Wellcome Trust)Find a programme
|Run by||Faculty of Biomedical Sciences|
|Programme length||Four years full-time|
|Location of programme||Clifton campus|
|Part-time study available||No, full-time only|
|Open to international students||
Funding for this programme is open to Home/EU students and non-Home/EU students.
|Number of places||5-6|
|Start date||September 2017|
This programme brings together the skills and expertise of more than 25 internationally recognised molecular cell biologists, who provide training in a broad range of cell biology topics and techniques: from analysing dynamic behaviour of cells in organisms to studies of intracellular behaviour and now progression into single molecules and high-resolution electron microscopy. Training also covers the spectrum from the purest studies of fundamental cell biology through to direct and translational application to human disease.
We are looking for talented and motivated students who are willing to take up the many varied challenges in cell biology and are open to learning about new disciplines and working across different fields.
Fees for 2017/18
Fees quoted are provisional, per annum and subject to annual increase.
University of Bristol students and graduates can benefit from a ten per cent reduction in tuition fees for postgraduate study. Check your eligibility for an alumni scholarship.
Funding for 2017/18
This programme is fully funded by the Wellcome Trust. The trust provides funding to cover PhD programme fees at UK/EU student rate, research expenses, a stipend for living expenses, contribution towards travel and a contribution towards transferable-skills training.
Further information on funding for prospective UK, EU and international postgraduate students.
You will have the opportunity to study a range of research topics, with different supervisors and undertake three 10-week laboratory-based research projects.
Your first rotation will be in a cellular lab, where you'll gain experience in cell culture and standard wide-field/confocal cell imaging alongside super-resolution imaging.
Your second rotation will be in a disease/model organism lab to extend skills into in vivo applied context and in techniques such as multiphoton imaging.
Finally, your third rotation will be in a molecular lab to become familiar with in vitro biochemical and biophysical methods, including protein production, complex assembly, functional reconstitution, high-resolution electron microscopy and single molecular imaging.
Write-ups, posters and presentations on the three rotation projects are completed by the end of June, providing you with three months in which to select your full PhD laboratory and focus on your proposed research project before the second year starts.
Second to fourth years
You will join a single laboratory for the remaining years of your PhD. On occasions there may be collaborative projects between two participating labs.
After your first year, you will be integrated into the PhD programme of your host school, which will depend on your chosen topic. These school programmes are similar to one another but not identical. In general, they involve submission of an end-of-year progress report to the departmental postgraduate tutor and an afternoon of seminars presented by your year cohort in that school, and subsequently an informal interview/viva with the postgraduate tutor or another senior academic. You will also remain under the wing of the Dynamic Molecular Cell Biology programme itself which has its own monitoring procedure.
First-class or upper second-class undergraduate degree or Master's degree in a biomedical science discipline or a relevant theoretical discipline. Crucially, we are looking for talented and motivated students who are willing to take up the many varied challenges in molecular cell biology and are open to learning about new disciplines and working across different fields.
See international equivalent qualifications on the International Office website.
|Application method||Online application form|
|English language requirements||
Further information about English language requirements
|Admissions statement||Read the programme admissions statement for important information on entry requirements, the application process and supporting documents required.|
Core research areas are:
- multiprotein complexes in gene maintenance and expression;
- dynamic organisation, regulation and re-modelling of the cytoskeleton;
- molecular complexes involved in protein translocation and trafficking;
- cell organisation, morphogenesis and tissue function;
- cancer, neuroscience, infection and immunity, cardiovascular biology.
- Professor Peter Cullen
- Professor Jo Adams
- Dr Jon Hanley
- Professor Jeremy Henley
- Dr Jon Lane
- Professor Harry Mellor
- Dr Stuart Mundell
- Professor Catherine Nobes
- Professor David Stephens
- Dr Paul Verkade
- Professor Ian Collinson
- Professor Imre Berger
- Dr Ariel Blocker
- Dr Anna Chambers
- Professor Mark Dillingham
- Dr Abdu Essaffi
- Dr Abder Kaidi
- Professor Stefan Roberts
- Professor Nigel Savery
- Professor Christiane Berger-Schaffitzel
- Professor Mark Szczelkun
- Disease/model organism
- Professor Paul Martin
- Dr Chrissy Hammond
- Professor Chris Paraskeva
- Professor Alastair Poole
- Dr Ash Toye
- Professor Ann Williams
- Professor Will Wood
- Professor Christoph Wuelfing
The vast majority of graduates go on to perform postdoctoral research in world-leading laboratories in the UK, Europe and the US. Some students have taken graduate-level entry to study medicine or entered teacher training programmes.
Professor Jo Adams, (Professor), Role of Signaling to the Cytoskeleton by the Extracellular Matrix in Cell Motility Processes
Professor Peter Cullen, (Professor), Endosomal sorting and signaling
Dr Abdelkader Essafi, (Lecturer), Molecular basis of embryonic processes in health and disease
Dr Jon Hanley, (Reader), The molecular mechanisms of synaptic plasticity
Professor Jeremy Henley, (Professor), Neurotransmitter receptor trafficking in plasticity and disease
Dr Jon Lane, (Reader), Molecular regulation of autophagy
Professor Harry Mellor, (Professor), Endothelial cell dynamics in angiogenesis
Professor Catherine Nobes, (Professor), Regulation of cell migration and cancer cell invasion by Eph receptors and ephrins
Professor David Stephens, (Professor), Protein trafficking through the early secretory pathway.
Dr Paul Verkade, (Reader), Visualising of protein trafficking/translocation events.
Dr Chrissy Hammond, (Reseach Fellow), Modelling osteoarthritis in zebrafish: looking at cell ' decision making' in the joint
Professor Paul Martin, (Professor), Inflammation in repair and cancer
Dr Stuart Mundell, (Reader), G protein-coupled receptor function and signalling in atherothrombosis
Professor Chris Paraskeva, (Professor), Colon cancer, the tumour microenvironment and cell survival
Professor Alastair Poole, (Professor), Platelet Cell Biology
Dr Ash Toye, (Senior Lecturer), Red blood cell development in health and disease.
Professor Ann Williams, (Professor), Colorectal tumour cell survival mechanisms and chemoprevention
Professor Will Wood, (Professor), Blood cell migration during inflammation and infection
Professor Christoph Wuelfing, (Professor), The spatiotemporal organization of lymphocyte signalling as a regulator of function
Professor Imre Berger, (Professor)
Professor Christiane Berger-Schaffitzel, (Professor), Ribosomal complexes in protein targeting, translocation and quality control
Dr Ariel Blocker, (Reader), Molecular mechanisms powering a bacterial toxin injection device
Dr Anna Chambers, (Fellow), Chromatin Remodelling and Genome Stability
Professor Ian Collinson, (Professor), Understanding the mechanism of protein secretion and mitochondrial import
Professor Mark D Szczelkun, (Professor), Molecular Mechanisms of Genome Processing and Maintenance
Professor Mark Dillingham, (Professor), Helicases as modular components of DNA processing machines
Dr Abderrahmane Kaidi, (Senior Lecturer), The dynamics of nuclear and genome topology
Professor Stefan Roberts, (Professor), Mechanisms of transcriptional regulation in mammalian cells
Professor Nigel Savery, (Professor)
Midday on 6 January 2017.
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