NICE Guidelines Technical Support Unit (TSU)

The NICE Guidelines Technical Support Unit (TSU) is based within the Multi-Parameter Evidence Synthesis (MPES) group in the Department of Population Health Sciences at Bristol Medical School. It began in 2011 and is funded through The NICE Centre for Guidelines until 2018.

The purpose of the TSU is three-fold:

  • To provide rapid response service to NICE and to the National Collaborating Centres on issues relating to evidence synthesis and economic modelling,
  • To provide training in evidence synthesis and economic modelling,
  • To carry out research as required.

The TSU consists of staff in Bristol and in external collaborating centres: Centre for Health Economics, University of York (Professor Mark Sculpher); the School of Health Related Research; University of Sheffield (Dr Sarah Davies, Professor Allan Wailoo) and the Department of Health Sciences, University of Leicester (Professor Keith Abrams).

In Bristol, the TSU is staffed by Dr Sofia Dias (Director and Senior Lead), Professor Nicky Welton (Deputy Director), Professor Tony Ades (Strategic Support), Edna Keeney (Health Economics Coordinator), and Caitlin Daly (Scientific Coordinator and Statistician).

Recent work of the TSU

  • Publications and conference presentations

Keeney, E, Dias, S & Dawoud, D, 2017, ‘Different Methods for Modelling Severe Hypoglycaemic Events: Implications for Effectiveness and Cost-Effectiveness Analyses’. in: Value in Health., pp. A408. Keeney E - ISPOR presentation 2017 (PDF, 393kB)

Phillippo, D.M., Elsada, A., Belger, M., Welton, N.J. 2017. Population-adjusted treatment comparisons in Health Technology Assessment: an overview of approaches and perspectives. Workshop presented at ISPOR 20th Annual European Congress. Phillippo D - population-adjusted indirect comparisons (PDF, 1,207kB)

Phillippo DM, Dias S, Ades AE, Didelez V, Welton NJ. Sensitivity of treatment recommendations to bias in Network Meta-Analysis. Journal of the Royal Statistical Society: Series A, available online 6 December 2017. [Free full text]

The accompanying R package nmathresh is available on CRAN.

Phillippo D, et al "Sensitivity of treatment decisions to bias adjustment in network meta-analysis (PDF, 2,962kB)"
Oral presentation at the 16th Biennial European Conference of the Society for Medical Decision Making, London, UK June 12 - June 14, 2016. 

  • NICE Guidelines

The TSU has contributed to the following guidelines (available from NICE):

Cystic fibrosis (NG78, 2017)

Endometriosis (NG73, 2017)

Parkinson’s disease in adults (NG71, 2017)

Eating Disorders (NG69, 2017)

Spondyloarthritis in over 16s (NG65, 2017)

Type 2 diabetes in adults (NG28, 2015)

Preterm labour and birth (NG25, 2015)

Headaches (CG150 Update, 2015)

Type 2 Diabetes in adults (Update, 2015)

Menopause (NG23, 2015)

Type 1 Diabetes (NG17, 2015)

Atrial Fibrillation (CG180, 2014)

Bipolar Disorder (CG185, 2014)

Urinary Incontinence in women (CG171, 2013)

Social Anxiety Disorder (CG159, 2013)

Neuropathic Pain (CG173, 2013)

Crohn’s Disease (CG152, 2012)

Acute upper GI bleeding (CG141, 2012)

Advanced or metastatic Colorectal Cancer (CG131, 2011)

  • Workshops

The TSU has delivered workshops on Network Meta-analysis; training on Methods for Diagnostic Synthesis, and methods for Guidelines involving Service Delivery.

For further information on courses see MPES courses and Bristol Medical School Short Courses.

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