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Dr Lucia Marucci

Dr Lucia Marucci

Dr Lucia Marucci
BSc, MSc, PhD

Senior Lecturer in Systems & Synthetic Biology

Area of research

Quantitative understanding and control of cell complexity and decision-making

Office 2.51
Merchant Venturers Building,
Woodland Road, Clifton BS8 1UB
(See a map)

+44 (0) 117 331 4760

Summary

Cell decision-making is orchestrated by the complex interplay between intracellular dynamics and the extracellular environment. How do these components produce emergent phenotypes and affect cell decision-making? Can cell fate be directly engineered? Can mathematical models aid in the understanding the basis of living organism regulations and guide their re-engineering?

My multidisciplinary Systems and Synthetic Biology research group aims at answering these questions combining wet-lab experiments and computational research. The main aims are to:

i) get a quantitative understanding of the link between signalling pathway dynamics, cell-cycle and stem cell pluripotency. We combine tools from Systems and Synthetic Biology at population- and single-cell levels, and are currently setting-up a microscopy/microfluidics platform for real-time mammalian cells imaging and control;

ii) develop agent-based modelling tools for describing and predicting single-cell dynamics accounting for gene regulatory networks, cell morphology, cell growth and geometry of the environment;

iii) use in silico algorithms for rational minimal genome design, taking advantage of Whole-Cell models

Biography

I am a computational biology scientist, with 10 years research experience in Synthetic Biology (control and modelling of synthetic gene regulatory networks) and Systems Biology (modelling and studying the functional role of signalling and cell-cycle dynamics in mammalian cells).

I received a Bachelor degree in Mathematics in the University of L'Aquila (Italy) in 2003, followed in 2007 by a Master degree in Mathematics and Informatics in the same University. In 2010 I received a Ph.D. degree in Automatic Engineering in the University of Naples "Federico II", Italy. My Ph.D. was focused on the mathematical modelling and analysis of synthetic gene regulatory networks. From 2011 to 2013 I was a PostDoc EMBO fellow in the Centre for Genomic Regulation (CRG), Barcelona, Spain, studying the links between signalling pathways dynamics and somatic cell reprogramming. In September 2013 I joined Bristol University as Lecturer in Engineering Mathematics.

 

Teaching

I contribute to both undergraduate and postgraduate programmes

I am unit-director of the Mathematical Modelling in Physiology and Medicine unit (M level), and teach part of Engineering Mathematics 1 and MDM2 units.

I contribute to teaching activities of the BBSRC/EPSRC Centre for Doctoral Training in Synthetic Biology (Bristol, Oxford and Warwick Universities).

Keywords

  • Systems Biology
  • Synthetic Biology
  • Pluripotency
  • Non-linear dynamics
  • Microfluidics

Memberships

Organisations

Department of Engineering Mathematics

Other sites

Recent publications

View complete publications list in the University of Bristol publications system

Courses

Dr Marucci currently teaches 4 courses:

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