Dr Jonathan Brooks

Research interests

My main interests are pain research and neuroscience in general, which I study using a variety of techniques e.g. functional neuroimaging, magnetic resonance spectroscopy and diffusion weighted imaging. Recently I have developed new techniques for acquiring functional imaging data from the spinal cord, which is a key relay point for integration and transmission of nociceptive signals from the peripheral nervous system, and the first point in the central nervous system (CNS) where these signals are processed.

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Current research grants

• 2008-2012 Medical Research Council Functional magnetic resonance imaging of the human spinal cord and brainstem with application to pain states
• 2010-2012 Oxfordshire Health Services Research Committee Investigating the integrity of CNS functions in the spinal cord-injured patient using fMRI
• 2011-2013 International Association for the Study of Pain Investigating altered function and connectivity in the spinal cord and brainstem of patients with neuropathic pain

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Publications

• Jonathan Brooks, Yazhuo Kong, Michael Lee, Katie Warnaby, Vishvarani Wanigasekera, Mark Jenkinson, and Irene Tracey. Stimulus site and modality dependence of functional activity within the human spinal cord. J Neuroscience (In Press)
• Yazhuo Kong, Mark Jenkinson, Jesper Anderrson, Irene Tracey and Jonathan Brooks. Assessment of physiological noise modelling methods for functional imaging of the spinal cord. (2011) doi:10.1016/j.neuroimage.2011.11.077
• Eve H Oldfield, Jonathan CW Brooks, Richard JS Wise, Francesco Padormo, Jo V Hajnal, Christian F Beckmann, Mark A Ungless. Identification and characterisation of midbrain nuclei using optimised functional magnetic resonance imaging (2012). NeuroImage 59: 1230-1238
• Cohen-Adad J, Gauthier CJ, Brooks JC, Slessarev M, Han J, Fisher JA, Rossignol S, Hoge RD  (2010) BOLD signal responses to controlled hypercapnia in human spinal cord. Neuroimage. 50: 1074-84
• Brooks JCW, Beckmann C, Miller KL, Wise R, Porro CA, Tracey I, Jenkinson M (2008). Physiological noise modelling for spinal functional magnetic resonance imaging studies. NeuroImage. 39:680-692
• Harvey AK, Pattinson KT, Brooks JC, Mayhew SD, Jenkinson M, Wise RG (2008). Brainstem functional magnetic resonance imaging: disentangling signal from physiological noise. J Magn Reson Imaging. 28:1337-44
• Leknes S, Brooks JC, Wiech K, Tracey I (2008). Pain relief as an opponent process: a psychophysical investigation. Eur J Neuroscience. 28: 794-801
• Hussain Z, Brooks J, Percy D (2008). Menstrual variation of breast volume and T¬2 relaxation times in cyclical mastalgia. Radiography. 14: 8-16
• Sluming V, Brooks J, Howard M, Downes J, Roberts N (2007). Broca's area supports enhanced visuospatial cognition in orchestral musicians. J Neurosci. 27: 3799-3806
• Brooks J & Tracey I (2007). The insula: a multidimensional integration site for pain. Pain. 128:1-2 Editorial
• Dunckley P, Aziz Q, Wise RG, Brooks J, Tracey I, Chang L (2007). Attentional modulation of visceral and somatic pain. Neurogastroenterol Motil. 19:569-77
• Schweinhardt P, Glynn C, Brooks J, McQuay H, Jack T, Chessell I, Bountra C, Tracey I (2006). An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients. Neuroimage. 32:256-65
• Brooks JC, Zambreanu L, Godinez A, Craig AD, Tracey I (2005). Somatotopic organisation of the human insula to painful heat studied with high resolution functional imaging. Neuroimage. 27:201-9
• Brooks J, Tracey I (2005). From nociception to pain perception: imaging the spinal and supraspinal pathways. J Anat. 207:19-33. Review
• Tjandra T, Brooks JC, Figueiredo P, Wise R, Matthews PM, Tracey I (2005). Quantitative assessment of the reproducibility of functional activation measured with BOLD and MR perfusion imaging: implications for clinical trial design. Neuroimage. 27:393-401
• Zambreanu L, Wise RG, Brooks JC, Iannetti GD, Tracey I (2005). A role for the brainstem in central sensitisation in humans. Evidence from functional magnetic resonance imaging. Pain. 114:397-407
• Iannetti GD, Brooks JC (2005). On the interpretation of temporal differences of BOLD fMRI responses to nociceptive stimulation. J Neurophysiol. 93:3718-9
• Dunckley P, Wise RG, Aziz Q, Painter D, Brooks J, Tracey I, Chang L (2005). Cortical processing of visceral and somatic stimulation: differentiating pain intensity from unpleasantness. Neuroscience. 133:533-42
• Iannetti GD, Niazy RK, Wise RG, Jezzard P, Brooks JC, Zambreanu L, Vennart W, Matthews PM, Tracey I (2005). Simultaneous recording of laser-evoked brain potentials and continuous, high-field functional magnetic resonance imaging in humans. Neuroimage. 28:708-19
• Bowsher D, Brooks J, Enevoldson P (2004).  Central representation of somatic sensations in the parietal operculum (SII) and insula. Eur Neurol. 52:211-25
• Brooks JCW, Bimson WE, Roberts N, Nurmikko TJ. Functional magnetic resonance imaging of capsaicin-induced thermal hyperalgesia. In: Dostrovsky J, Carr D and Koltzenburg M, editors. Proceedings of the 10th World Congress on Pain. Vol 24. Seattle: IASP Press, 2003: 295-304.
• Brooks JCW, Nurmikko TJ, Singh KD, Bimson WE, Roberts N (2002). fMRI of thermal pain: effects of stimulus laterality and attention. NeuroImage. 15: 293-301
• Brooks JCW, Roberts N, Kemp GJ, Gosney MA, Lye M, Whitehouse GH (2001). A proton magnetic resonance spectroscopy study of age-related changes in frontal lobe metabolite concentrations. Cerebral Cortex. 11:598-605
• Brooks JCW, Roberts N, Whitehouse G, Majeed T (2000). Proton magnetic resonance spectroscopy and morphometry of the hippocampus in chronic fatigue syndrome. British Journal of Radiology. 73:1206-1208
• Brooks JCW, Roberts N, Kemp GJ, Martin PA, Whitehouse GH (1999). Magnetic Resonance Imaging based Compartmentation and its Application to Measuring Metabolite Concentrations in the Frontal Lobe. Magnetic Resonance in Medicine. 41: 883-888
• Keevil SF, Barbiroli B, Brooks JCW, Cady EB, Canese Carlier P, Collins DJ, Gilligan P, Gobbi G, Hennig J, Kugel H, Leach MO, Metzler D, Mlynarik V, Mosler E, Newbold MC, Payne GS, Ring P, Roberts JN, Rowland IJ, Thiel I, Tkac I, Topp S, Wittsack HJ, Wylezinska M, Zanoil P, Henriksen O, Podo F (1998). Absolute metabolite quantification by in vivo NMR spectroscopy: II. A multicentre trial of protocols for in vivo localised proton studies of human brain. Magnetic Resonance Imaging. 16: 1093-1106

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