BristolBridge Seminar - EMBRACEing antibiotic resistance research: from promoting immune clearance to targeting bacterial DNA quadruplexes
Dr Lindsay Evans, Imperial College, London
School of Chemistry, LT4
BristolBridge Seminar - Dr Lindsay Evans, Imperial College, London
EMBRACEing antibiotic resistance research: from promoting immune clearance to targeting bacterial DNA quadruplexes
EMBRACE is part of the EPSRC sponsored 'Bridging the Gaps' initiative, its purpose is to nurture multidisciplinary research within Imperial College and challenge the catastrophic threat of antimicrobial resistance. During the two-year initiative numerous collaborations and research projects have been established, several of which have been based in the chemical and life sciences and examine novel mechanisms for targeting drug-resistant bacteria. The development of new antibiotic classes with mechanisms of action distinct from existing antibiotics is integral to tackling AMR.
Dr Evans will talk about her work on developing inhibitors of the DNA repair complexes AddAB and RecBCD to promote immune clearance and overcome resistance to DNA damaging antimicrobials, investigating the importance of DNA quadruplexes in regulating genes associated with antibiotic resistance in Pseudomonas aeruginosa, and exploiting mechanisms of beta-lactam resistance to selectively deliver antibacterial agents to resistant bacteria.
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