PhD Dynamic Molecular Cell Biology (Wellcome Trust)

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Publications

See the most recent published work from our students below, or download the Full list of publications (Updated to 2023) (PDF, 276kB)

2023

  • Dunkley, S., & Mogessie, B. (2023). Actin limits egg aneuploidies associated with female reproductive aging. Science Advances, 9(3). DOI: 10.1126/sciadv.adc9161
  • Bergen, D. J. M., Maurizi, A., Formosa, M. M., McDonald, G. L. K., El-Gazzar, A., Hassan, N., Brandi, M. L., Riancho, J. A., Rivadeneira, F., Ntzani, E., Duncan, E. L., Gregson, C. L., Kiel, D. P., Zillikens, M. C., Sangiorgi, L., Högler, W., Duran, I., Mäkitie, O., van Hul, W., & Hendrickx, G. (2023). High Bone Mass Disorders: New Insights From Connecting the Clinic and the Bench. Journal of Bone and Mineral Research, 38(2), 229–247. https://doi.org/10.1002/JBMR.4715
  • Needs, H. I., Pereira, G. C., Henley, J. M., & Collinson, I. (2023). The NanoLuc Assay System for Accurate Real-Time Monitoring of Mitochondrial Protein Import within Intact Mammalian Cells. JMB https://doi.org/10.1016/j.jmb.2023.168129
  • Jiménez-Moreno N, Kollareddy M, Stathakos P, Moss JJ, Antón Z, Shoemark DK, Sessions RB, Witzgall R, Caldwell M, Lane JD. (2023) ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience. doi: 10.1083/jcb.201910133

2022

  • George, A., & Martin, P. (2022). Wound Healing Insights from Flies and Fish. Cold Spring Harbor Perspectives in Biology, 14(11), a041217. https://doi.org/10.1101/CSHPERSPECT.A041217
  • López-Cuevas, P., Xu, C., Severn, C. E., Oates, T. C. L., Cross, S. J., Toye, A. M., Mann, S., Martin, P., López-Cuevas, P., Severn, C. E., Oates, T. C. L., Toye, A. M., Martin, P., Xu, C., & Mann, S. (2022). Macrophage Reprogramming with Anti-miR223-Loaded Artificial Protocells Enhances In Vivo Cancer Therapeutic Potential. Advanced Science, 9(35), 2202717. https://doi.org/10.1002/ADVS.202202717
  • Tsuji, C., & Dodding, M. P. (2022). Lumenal components of cytoplasmic microtubules. Biochemical Society Transactions, 50(6), 1953–1962. https://doi.org/10.1042/BST20220851
  • Parker, C., Chambers, A. C., Flanagan, D. J., Ho, J. W. Y., Collard, T. J., Ngo, G., Baird, D. M., Timms, P., Morgan, R. G., Sansom, O. J., & Williams, A. C. (2022). BCL-3 loss sensitises colorectal cancer cells to DNA damage by targeting homologous recombination. DNA Repair, 115, 103331. https://doi.org/10.1016/J.DNAREP.2022.103331
  • Rice, C. M., Lewis, P., Ponce-Garcia, F. M., Gibbs, W., Groves, S., Cela, D., Hamilton, F., Arnold, D., Hyams, C., Oliver, E., Barr, R., Goenka, A., Davidson, A., Wooldridge, L., Finn, A., Rivino, L., & Amulic, B. (2022). Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19. Life Science Alliance, 6(2), 1-13. [e202201658]. https://doi.org/10.26508/lsa.202201658

2021

  • Torres Montaguth, O. E., Cross, S. J., Ingram, K. W. A., Lee, L., Diffin, F. M., & Szczelkun, M. D. (2021). ENDO-Pore: high-throughput linked-end mapping of single DNA cleavage events using nanopore sequencing. Nucleic Acids Research, 49(20), e118–e118. https://doi.org/10.1093/NAR/GKAB727
  • Stathakos, P., Jiménez-Moreno, N., Crompton, L. A., Nistor, P. A., Badger, J. L., Barbuti, P. A., Kerrigan, T. L., Randall, A. D., Caldwell, M. A., & Lane, J. D. (2021). A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons. Autophagy, 17(4), 855–871. https://doi.org/10.1080/15548627.2020.1739441/SUPPL_FILE/KAUP_A_1739441_SM4705.ZIP
  • Campbell, J. S., Davidson, A. J., Todd, H., Rodrigues, F. S. L. M., Elliot, A. M., Early, J. J., Lyons, D. A., Feng, Y., & Wood, W. (2021). PTPN21/Pez Is a Novel and Evolutionarily Conserved Key Regulator of Inflammation In Vivo. Current Biology, 31(4), 875-883.e5. https://doi.org/10.1016/J.CUB.2020.11.014
  • Henley, J. M., Nair, J. D., Seager, R., Yucel, B. P., Woodhall, G., Henley, B. S., Talandyte, K., Needs, H. I., & Wilkinson, K. A. (2021). Kainate and AMPA receptors in epilepsy: Cell biology, signalling pathways and possible crosstalk. Neuropharmacology, 195. https://doi.org/10.1016/J.NEUROPHARM.2021.108569
  • Henley, J. M., Seager, R., Nakamura, Y., Talandyte, K., Nair, J., & Wilkinson, K. A. (2021). SUMOylation of synaptic and synapse-associated proteins: An update. Journal of Neurochemistry, 156(2), 145–161. https://doi.org/10.1111/jnc.15103
  • Nair, J. D., Braksator, E., Yucel, B. P., Fletcher-Jones, A., Seager, R., Mellor, J. R., Bashir, Z. I., Wilkinson, K. A., & Henley, J. M. (2021). Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD. IScience, 24(9). https://doi.org/10.1016/J.ISCI.2021.103029
  • Zhao, X., Alibhai, D., Sun, T., Khalil, J., Hutchinson, J. L., Olzak, K., Williams, C. M., Li, Y., Sessions, R., Cross, S., Seager, R., Aungraheeta, R., Leard, A., Mckinnon, C. M., Phillips, D., Zhang, L., Poole, A. W., Banting, G., & Mundell, S. J. (2021). Tetherin/BST2, a physiologically and therapeutically relevant regulator of platelet receptor signalling. https://doi.org/10.1182/bloodadvances.2020003182
  • Parker, C., Chambers, A. C., Flanagan, D., Collard, T. J., Ngo, G., Baird, D. M., Timms, P., Morgan, R. G., Sansom, O., & Williams, A. C. (2021). Loss of BCL-3 sensitises colorectal cancer cells to DNA damage, revealing a role for BCL-3 in double strand break repair by homologous recombination. BioRxiv, 2021.08.03.454995. https://doi.org/10.1101/2021.08.03.454995
  • Needs, H. I., Protasoni, M., Henley, J. M., Prudent, J., Collinson, I., & Pereira, G. C. (2021). Interplay between mitochondrial protein import and respiratory complexes assembly in neuronal health and degeneration. Life, 11(5), 432. https://doi.org/10.3390/LIFE11050432/S1
  • Moss, J. J., Wirth, M., Tooze, S. A., Lane, J. D., & Hammond, C. L. (2021). Autophagy coordinates chondrocyte development and early joint formation in zebrafish. FASEB Journal, 35(11). https://doi.org/10.1096/FJ.202101167R
  • McGowan, L. M., Kague, E., Vorster, A., Newham, E., Cross, S., & Hammond, C. L. (2021). Wnt16 Elicits a Protective Effect Against Fractures and Supports Bone Repair in Zebrafish. JBMR Plus, 5(3). https://doi.org/10.1002/JBM4.10461
  • Dietrich, K., Fiedler, I. A. K., Kurzyukova, A., López-Delgado, A. C., McGowan, L. M., Geurtzen, K., Hammond, C. L., Busse, B., & Knopf, F. (2021). Skeletal Biology and Disease Modeling in Zebrafish. Journal of Bone and Mineral Research, 36(3), 436–458. https://doi.org/10.1002/JBMR.4256
  • Scott, A., Sueiro Ballesteros, L., Bradshaw, M., Tsuji, C., Power, A., Lorriman, J., Love, J., Paul, D., Herman, A., Emanueli, C., & Richardson, R. J. (2021). In Vivo Characterization of Endogenous Cardiovascular Extracellular Vesicles in Larval and Adult Zebrafish. Arteriosclerosis, Thrombosis, and Vascular Biology, 41(9), 2454–2468. https://doi.org/10.1161/ATVBAHA.121.316539
  • McDonald, G. L. K., Wang, M., Hammond, C. L., & Bergen, D. J. M. (2021). Pharmacological Manipulation of Early Zebrafish Skeletal Development Shows an Important Role for Smad9 in Control of Skeletal Progenitor Populations. Biomolecules 2021, Vol. 11, Page 277, 11(2), 277. https://doi.org/10.3390/BIOM11020277
  • Scott, A., Sueiro Ballesteros, L., Bradshaw, M., Tsuji, C., Power, A., Lorriman, J., Love, J., Paul, D., Herman, A., Emanueli, C., & Richardson, R. J. (2021). In Vivo Characterization of Endogenous Cardiovascular Extracellular Vesicles in Larval and Adult Zebrafish. Arteriosclerosis, Thrombosis, and Vascular Biology, 41(9), 2454–2468. https://doi.org/10.1161/ATVBAHA.121.316539

2020

  • Young, H. S., McGowan, L. M., Jepson, K. A., & Adams, J. C. (2020). Impairment of cell adhesion and migration by inhibition of protein disulphide isomerases in three breast cancer cell lines. Bioscience Reports, 40(10), 20193271. https://doi.org/10.1042/BSR20193271/226652
  • Kollárovič, G., Topping, C. E., Shaw, E. P., & Chambers, A. L. (2020). The human HELLS chromatin remodelling protein promotes end resection to facilitate homologous recombination and contributes to DSB repair within heterochromatin. Nucleic Acids Research, 48(4), 1872–1885. https://doi.org/10.1093/NAR/GKZ1146
  • Ryan, R., Moyse, B. R., & Richardson, R. J. (2020). Zebrafish cardiac regeneration—looking beyond cardiomyocytes to a complex microenvironment. Histochemistry and Cell Biology 2020 154:5, 154(5), 533–548. https://doi.org/10.1007/S00418-020-01913-6
  • Moyse, B. R., & Richardson, R. J. (2020). A Population of Injury-Responsive Lymphoid Cells Expresses mpeg1.1 in the Adult Zebrafish Heart. ImmunoHorizons, 4(8), 464–474. https://doi.org/10.4049/IMMUNOHORIZONS.2000063
  • Lawrence, E. A., Hammond, C. L., & Blain, E. J. (2020). Potential of zebrafish as a model to characterise MicroRNA profiles in mechanically mediated joint degeneration. Histochemistry and Cell Biology, 154(5), 521–531. https://doi.org/10.1007/S00418-020-01918-1/TABLES/1
  • Daly, J. L., Simonetti, B., Klein, K., Chen, K. E., Williamson, M. K., Antón-Plágaro, C., Shoemark, D. K., Simón-Gracia, L., Bauer, M., Hollandi, R., Greber, U. F., Horvath, P., Sessions, R. B., Helenius, A., Hiscox, J. A., Teesalu, T., Matthews, D. A., Davidson, A. D., Collins, B. M., … Yamauchi, Y. (2020). Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science, 370(6518), 861–865. DOI: 10.1126/science.abd3072
  • Seager, R., Lee, L., Henley, J. M. M., & Wilkinson, K. A. A. (2020). Mechanisms and roles of mitochondrial localisation and dynamics in neuronal function. Neuronal Signaling, 4(2), 20200008. https://doi.org/10.1042/NS20200008
  • Legge, D. N., Chambers, A. C., Parker, C. T., Timms, P., Collard, T. J., & Williams, A. C. (2020). The role of B-Cell Lymphoma-3 (BCL-3) in enabling the hallmarks of cancer: implications for the treatment of colorectal carcinogenesis. Carcinogenesis, 41(3), 249–256. https://doi.org/10.1093/CARCIN/BGAA003
  • Moss, J. J., Hammond, C. L., & Lane, J. D. (2020). Zebrafish as a model to study autophagy and its role in skeletal development and disease. Histochemistry and Cell Biology, 154(5), 549–564. https://doi.org/10.1007/S00418-020-01917-2/FIGURES/4
  • Alvira, S., Watkins, D. W., Troman, L., Allen, W. J., Lorriman, J. S., Degliesposti, G., Cohen, E. J., Beeby, M., Daum, B., Gold, V. A. M., Mark Skehel, J., & Collinson, I. (2020). Inter-membrane association of the sec and bam translocons for bacterial outer-membrane biogenesis. ELife, 9, 1–24. https://doi.org/10.7554/ELIFE.60669 

2019

  • Simonetti, B., & Cullen, P. J. (2019). Actin-dependent endosomal receptor recycling. Current Opinion in Cell Biology, 56, 22–33. https://doi.org/10.1016/j.ceb.2018.08.00

  • Stathakos, P., Jimenez-Moreno, N., Crompton, L., Nistor, P., Caldwell, M. A., & Lane, J. D. (2019). Imaging Autophagy in hiPSC-Derived Midbrain Dopaminergic Neuronal Cultures for Parkinson’s Disease Research. Methods in Molecular Biology (Clifton, N.J.), 1880, 257–280. https://doi.org/10.1007/978-1-4939-8873-0_17
  • Needs, H. I., Henley, B. S., Cavallo, D., Gurung, S., Modebadze, T., Woodhall, G., & Henley, J. M. (2019). Changes in excitatory and inhibitory receptor expression and network activity during induction and establishment of epilepsy in the rat Reduced Intensity Status Epilepticus (RISE) model. Neuropharmacology, 158, 107728. https://doi.org/10.1016/J.NEUROPHARM.2019.107728
  • Anderson, M. W., Moss, J. J., Szalai, R., & Lane, J. D. (2019). Mathematical Modeling Highlights the Complex Role of AKT in TRAIL-Induced Apoptosis of Colorectal Carcinoma Cells. IScience, 12, 182–193. https://doi.org/10.1016/J.ISCI.2019.01.015
  • McGowan, L. M., Davey Smith, G., Gaunt, T. R., & Richardson, T. G. (2019). Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic disease. Human Molecular Genetics, 28(19), 3293–3300. https://doi.org/10.1093/HMG/DDZ155

2018

  • Daly, J. L., & Cullen, P. J. (2018). Endoplasmic Reticulum–Endosome Contact Sites: Specialized Interfaces for Orchestrating Endosomal Tubule Fission? Biochemistry, 57(49), 6738–6740. https://doi.org/10.1021/acs.biochem.8b01176

  • Gurevich, D. B., Severn, C. E., Twomey, C., Greenhough, A., Cash, J., Toye, A. M., … Martin, P. (2018). Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression. The EMBO Journal, 37(13), e97786. https://doi.org/10.15252/embj.201797786
  • Gurung, S., Evans, A. J., Wilkinson, K. A., & Henley, J. M. (2018). ADAR2-mediated Q/R editing of GluK2 regulates kainate receptor upscaling in response to suppression of synaptic activity. Journal of Cell Science, 131(24), jcs222273. https://doi.org/10.1242/jcs.222273
  • Hawkins, S. J., Crompton, L. A., Sood, A., Saunders, M., Boyle, N. T., Buckley, A., Minogue, A. M., McComish, S. F., Jiménez-Moreno, N., Cordero-Llana, O., Stathakos, P., Gilmore, C. E., Kelly, S., Lane, J. D., Case, C. P. & Caldwell, M. A. (2018). Nanoparticle-induced neuronal toxicity across placental barriers is mediated by autophagy and dependent on astrocytes. Nature Nanotechnology, 13(5), 427–433. https://doi.org/10.1038/s41565-018-0085-3
  • Healy, M. D., Hospenthal, M. K., Hall, R. J., Chandra,M., Chilton, M., Tillu, V., … Ghai, R. (2018). Structural insights into the architecture and membrane interactions of the conserved COMMD proteins. ELife, 7. https://doi.org/10.7554/eLife.35898
  • Heideveld, E., Hampton-O’Neil, L. A., Cross, S. J., van Alphen, F. P. J., van den Biggelaar, M., Toye, A. M., & van den Akker, E. (2018). Glucocorticoids induce differentiation of monocytes towards macrophages that share functional and phenotypical aspects with erythroblastic island macrophages. Haematologica, 103(3), 395–405. https://doi.org/10.3324/haematol.2017.179341 
  • Lawrence, E. A., Kague, E., Aggleton, J. A., Harniman, R. L., Roddy, K. A., & Hammond, C. L. (2018). The mechanical impact of col11a2 loss on joints; col11a2 mutant zebrafish show changes to joint development and function, which leads to early-onset osteoarthritis. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 373(1759), 20170335. http://doi.org/10.1098/rstb.2017.0335
  • McGough, I. J., de Groot, R. E. A., Jellett, A. P., Betist, M. C., Varandas, K. C., Danson, C. M., … Cullen, P. J. (2018). SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion. Nature Communications, 9(1), 3737. https://doi.org/10.1038/s41467-018-06114-3
  • McNally, K. E., & Cullen, P. J. (2018). Endosomal Retrieval of Cargo: Retromer Is Not Alone. Trends in Cell Biology, 28(10), 807–822. https://doi.org/10.1016/j.tcb.2018.06.005
  • Pellegrin, S., Haydn-Smith, K. L., Hampton-O’Neil, L. A., Hawley, B. R., Heesom, K. J., Fermo, E., … Toye, A. M. (2018). Transduction with BBF2H7/CREB3L2 upregulates SEC23A protein in erythroblasts and partially corrects the hypo-glycosylation phenotype associated with CDAII. British Journal of Haematology. https://doi.org/10.1111/bjh.15189
  • Roloff, E. V. L., Walas, D., Moraes, D. J. A., Kasparov, S., & Paton, J. F. R. (2018). Differences in autonomic innervation to the vertebrobasilar arteries in spontaneously hypertensive and Wistar rats. The Journal of Physiology, 596(16), 3505–3529. https://doi.org/10.1113/JP275973
  • Simonetti, B., & Cullen, P. J. (2018). Endosomal Sorting: Architecture of the Retromer Coat. Current Biology : CB, 28(23), R1350–R1352. https://doi.org/10.1016/j.cub.2018.10.040
  • Stevenson, N. L., Bergen, D. J. M., Xu, A., Wyatt, E., Henry, F., McCaughey, J., … Stephens, D. J. (2018). Regulator of calcineurin-2 is a centriolar protein with a role in cilia length control. Journal of Cell Science, 131(9), jcs212258. https://doi.org/10.1242/jcs.212258
  • Thuma, L., Carter, D., Weavers, H., & Martin, P. (2018). Drosophila immune cells extravasate from vessels to wounds using Tre1 GPCR and Rho signaling. The Journal of Cell Biology, 217(9), 3045–3056. https://doi.org/10.1083/jcb.201801013
  • Tilley, F. C., Gallon, M., Luo, C., Danson, C. M., Zhou, J., & Cullen, P. J. (2018). Retromer associates with the cytoplasmic amino-terminus of polycystin-2. Journal of Cell Science, 131(11), jcs211342. https://doi.org/10.1242/jcs.211342
  • Walas, D., Nowicki-Osuch, K., Alibhai, D., von Linstow Roloff, E., Coghill, J., Waterfall, C., & Paton, J. F. (2018). Inflammatory pathways are central to posterior cerebrovascular artery remodelling prior to the onset of congenital hypertension. Journal of Cerebral Blood Flow and Metabolism 271678X18769180. https://doi.org/10.1177/0271678X18769180

 

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