
Dr Parthive Patel
Expertise
Current positions
Sir Henry Dale Research Fellow
School of Cellular and Molecular Medicine
Contact
Press and media
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Research interests
Many of our tissues, like our skin or gut, lose cells from constant environmental insults, for example from pathogens or chemicals. Thus, a tissue’s ability to sense stress or damage, defend itself and replace spent cells to promote repair is key for its proper function, maintaining its integrity and preventing disease. Despite its importance, however, how tissues maintain epithelial integrity is poorly understood.
To better understand this process, we are using the adult fruit fly intestine, which is remarkably similar to our own gut. Together with genetic, biochemical, molecular and imaging techniques, we aim to determine how oxidants and damage-sensing signals trigger cells to defend themselves and support tissue repair upon injury. Additionally, we aim to determine whether biorhythmic cues received by tissues support their upkeep by fostering new cell production and to identify ways cells can survive longer to prolong tissue integrity when new cells can no longer be produced.
Our work could provide novel therapeutic strategies for tissue repair, inflammation, ageing and cancer.
Projects and supervisions
Publications
Recent publications
25/09/2019Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut
Nature Communications
Proteomics of Bronchoalveolar Lavage Fluid Reveals a Lung Oxidative Stress Response in Murine Herpesvirus-68 Infection.
Viruses
Intestinal Stem Cell Pool Regulation in Drosophila
Stem Cell Reports
Niche appropriation by Drosophila intestinal stem cell tumours
Nature Cell Biology
Regional Cell-Specific Transcriptome Mapping Reveals Regulatory Complexity in the Adult Drosophila Midgut
Cell Reports