Professor Mark Dillingham
B.Sc.(Bristol), Ph.D.(Oxon.)
Current positions
Professor of Biochemistry
School of Biochemistry
Contact
Press and media
Many of our academics speak to the media as experts in their field of research. If you are a journalist, please contact the University’s Media and PR Team:
Biography
Research interests
The Dillingham Laboratory is studying mechanistic aspects of DNA:protein interactions which underpin DNA replication, repair, recombination and segregation. At the moment we are especially interested in:
(1) DNA helicases as modular components of molecular machines
(2) The initiation of double-stranded DNA break repair and how it can be modulated for medical and biotech applications
(3) The role of helicases in suppressing replication:transcription conflicts
(4) The mechanism of chromosome individualisation and segregation by ParB and SMC complexes
(5) DNA mimic proteins and their potential applications in medicine and biotechnology
Join our group! We are always interested in hearing from talented scientists who wish to join the laboratory. Please contact Mark for an informal discussion of the opportunities that are currently available.
Projects and supervisions
Research projects
DNA Repair State Machines
Principal Investigator
Managing organisational unit
School of BiochemistryDates
01/05/2023 to 30/04/2027
Structure: Function Correlation in the Human DNA Repair Factor CtIP
Principal Investigator
Managing organisational unit
School of BiochemistryDates
01/06/2021 to 31/05/2024
Single-molecule DNA repair by homologous recombination in live bacterial cells
Principal Investigator
Managing organisational unit
School of BiochemistryDates
01/06/2019 to 31/05/2022
Thesis supervisions
Modulation of bacterial DNA repair efficiency
Supervisors
Characterisation of the HELLS and Irc5 subfamily of chromatin remodellers
Supervisors
Investigating Interactions Of The SecYEG Holotranslocon With Periplasmic Chaperones And Outer Membrane Proteins
Supervisors
A Baculoviral ‘Swag Bag’ Protein and DNA Delivery Toolkit for CRISPR-based Editing of Human Genomes
Supervisors
Experimental and Computational Studies of PcrA helicase Interactions with Partner Proteins
Supervisors
The role of the chromatin remodelling protein HELLS in maintaining genome stability
Supervisors
Publications
Recent publications
06/10/2023Recent insights into eukaryotic double-strand DNA break repair unveiled by single-molecule methods
Trends in genetics
Highly efficient CRISPR-mediated large DNA docking and multiplexed prime editing using a single baculovirus
Nucleic Acids Research
Human HELB is a processive motor protein that catalyzes RPA clearance from single-stranded DNA
Proceedings of the National Academy of Sciences of the United States of America
Long DNA constructs to study helicases and nucleic acid translocases using optical tweezers
Methods in Enzymology
Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub
eLife