Dr Laura Rivino
MSc, PhD
Expertise
Current positions
Associate Professor in Immunology
School of Cellular and Molecular Medicine
Contact
Press and media
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Research interests
Virus-specific T cells constitute an essential line of defence during viral infection and both an impaired or exacerbated T cell response are detrimental to the host. We are interested in understanding how T cells contribute to protective immunity and/or immunopathology during viral infection, particularly in the context of dengue virus infection, and more recently in COVID-19. Understanding these mechanisms is critical for the development of effective vaccines and immunomodulatory therapeutics.
We collaborate with scientists and clinicians at the Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City in Vietnam, the National Centre for Infectious Diseases (NCID) in Singapore, Duke-NUS Medical School in Singapore and North Bristol NHS Trust in Bristol, UK.
Projects and supervisions
Research projects
Combining shingles with either COVID-19 or adjuvanted influenza vaccine
Principal Investigator
Role
Co-Investigator
Managing organisational unit
Bristol Medical School (PHS)Dates
09/01/2023
Metabolic and functional profiling of CD4+ and CD8+ T cells in overweight/obese versus normal weight patients during dengue virus infection
Principal Investigator
Managing organisational unit
School of Cellular and Molecular MedicineDates
21/03/2022 to 20/03/2023
(CLOSED) 8049 CMM UK CIC Characterisation of COVID-19 long-term immunity (NCS_1) WP3
Principal Investigator
Managing organisational unit
School of Cellular and Molecular MedicineDates
01/10/2020 to 31/03/2021
UKCiC Characterization of COVID-19 long-term immunity (R101755-COA funding)
Principal Investigator
Managing organisational unit
School of Cellular and Molecular MedicineDates
01/10/2020 to 30/09/2021
8049 [CLOSED] CMM: A UK underpinning platform to study immunology and immunopathology of COVID- 19:The UK Coronavirus Immunology Consortium MR/V028448/1
Principal Investigator
Managing organisational unit
School of Cellular and Molecular MedicineDates
20/08/2020 to 19/08/2021
Thesis supervisions
Role of skin-based T cell immunity in acute dengue infection
Supervisors
Characterising genetic variants in the KLRK1 gene associated with severe dengue and their impact on the function of Natural Killer cells
Supervisors
Investigating the natural killer cell response in dengue virus infection
Supervisors
TIM3 is a context-dependent coregulator of cytotoxic T cell function
Supervisors
Comprehensive Investigation of Immune Cell Responses in Dengue Virus and SARS-CoV-2 Infections
Supervisors
Optimisation of a novel metabolic assay to study the features of PD1+ T cells in viral infection
Supervisors
Publications
Selected publications
17/12/2019Large-Scale HLA Tetramer Tracking of T Cells during Dengue Infection Reveals Broad Acute Activation and Differentiation into Two Memory Cell Fates
Immunity
NK cells are activated and primed for skin-homing during acute dengue virus infection in humans
Nature Communications
Virus-specific T lymphocytes home to the skin during natural dengue infection
Science Translational Medicine
Cross-Reactivity and Anti-viral Function of Dengue Capsid and NS3-Specific Memory T Cells Toward Zika Virus
Frontiers in Immunology
Differential targeting of viral components by CD4+ versus CD8+ T lymphocytes in dengue virus infection
Journal of Virology
Recent publications
15/08/2024Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19
The Journal of infectious diseases
Early NK-cell and T-cell dysfunction marks progression to severe dengue in patients with obesity and healthy weight
Early NK-cell and T-cell dysfunction marks progression to severe dengue in patients with obesity and healthy weight
Prolonged T-cell activation and long COVID symptoms independently associate with severe COVID-19 at 3 months
eLife
T Cells
eLife
Development and evaluation of low-volume tests to detect and characterize antibodies to SARS-CoV-2
Frontiers in Immunology
Related people
Professor Adam Finn
Professor of Paediatrics
Bristol Medical School (PHS)
Dr Fergus Hamilton
NIHR Clinical Lecturer
Bristol Medical School (PHS)
Professor Linda Wooldridge
Chair in Translational Immunology
Bristol Veterinary School
Dr Anu Goenka
Consultant Senior Lecturer in Paediatric Immunology and Infectious Diseases
Bristol Medical School (PHS)
Dr Alice Halliday
Lecturer
School of Cellular and Molecular Medicine