Professor Hans Reul
Professor of NeuroscienceBristol Medical School (THS)
My research group investigates how the organism responds and adapts to stressful events.
Major research interests are:
The signalling, epigenetic and genomic mechanisms in the brain underlying stress-related learning and memory processes.
The regulation of the hypothalamic-pituitary-adrenal (HPA) axis under baseline and stress conditions.
The physiological and neurobiological mechanisms underlying the beneficial effects of voluntary exercise on stress coping, HPA axis regulation, and anxiety-related and cognitive behaviour.
My research group investigates how the organism responds and adapts to stressful events. The emphasis is on how we learn and form memories of emotionally stressful events in our lives so we can respond better if such events should reoccur.
Our research programme addresses the role of signalling, epigenetic and genomic processes in the brain in the consolidation of adaptive behavioural responses and memory. Furthermore, we are investigating the role of adult neurogenesis in the dentate gyrus in these processes and responses.
Behavioural responses and memory formation are investigated in the forced swim test, Morris water maze learning and contextual fear conditioning. Our neuroanatomical and molecular expertise includes immuno-fluorescence analysis, lentiviral technology (in collaboration with Professor James Uney (UoB)) and state-of-the-art epigenetic methods such as chromatin-immuno-precipitation (nChIP, xChIP), next generation Illumina sequencing and bisulfite sequencing (in collaboration with Dr. Jon Mill, King’s College London).
Sex differences in stress-induced corticosteroid receptor interaction with the rat brain genome: Gene transcriptional and behavioural consequences
01/12/2021 to 30/11/2024
Epigenetic regulation of stress-induced glucocorticoid action in the dentate gyrus and its behavioural implications
01/09/2020 to 31/08/2023
An integrated epigenomic/transcriptomic approach to elucidate glucocorticoid-regulated gene networks in stress-related cognitive behaviour
01/02/2017 to 31/01/2021
Role of corticosteroid receptor DNA binding in stress-induced hippocampal gene transcription in relation to glucocorticoid and behavioural responses
01/10/2016 to 31/08/2020
01/10/2013 to 01/10/2016
Stress: Genetics, Epigenetics and Genomics
- Chapter in a book
The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice
Unexpected effects of metyrapone on corticosteroid receptor interaction with the genome and subsequent gene transcription in the hippocampus of male rats
Journal of Neuroendocrinology
Mineralocorticoid and glucocorticoid receptor-mediated control of genomic responses to stress in the brain
- E-pub ahead of print