I started my independent laboratory at the Ludwig Institute for Cancer Research, University College London, UK, progressing to a Professorship. I moved to King's College London in 2007 to become Professor of Cell Biology. At the University of Bristol, UK, I was Head of the School of Cellular and Molecular Medicine from January 2018 to December 2023.  I am Professor of Cell Biology. 
My laboratory studies cell migration, cell adhesion, and their links to cancer invasion and metastasis. We focus on intracellular signalling by Rho family GTPases and protein kinases, including how they are activated by cell surface receptors.
I am an elected Member of EMBO (European Molecular Biology Organization), a Fellow of the UK Academy of Medical Sciences, a Fellow of the Royal Society of Biology and a Fellow of the Royal Society.