Dr Alex Greenhough
Current positions
Honorary Senior Lecturer
School of Cellular and Molecular Medicine
Contact
Press and media
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Research interests
- The role of hypoxia (reduced tissue oxygen levels) in the tumour microenvironment
- Signal transduction pathways in cancer development (particularly Wnt/β-catenin and Hippo-YAP/TAZ)
- The role of autophagy in tissue homeostasis and cancer
- Apoptosis and tumour cell survival
- Cyclooxygenases (COX1 and COX2) and prostaglandins (particularly PGE2)
- Three-dimensional models of normal and cancer tissue (spheroid & organoid culture)
- Post-translational modifications and cancer epigenetics
- Drug resistance & novel targets for cancer therapy
Publications
Recent publications
06/02/2021Transcriptomic analyses of MYCN-regulated genes in anaplastic Wilms' tumour cell lines reveals oncogenic pathways and potential therapeutic vulnerabilities
Cancers
A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer
Cancer Epidemiology, Biomarkers and Prevention
A Wnt-BMP4 Signaling Axis Induces MSX and NOTCH Proteins and Promotes Growth Suppression and Differentiation in Neuroblastoma
Cells
BCL-3 promotes a cancer stem cell phenotype by enhancing β-catenin signalling in colorectal tumour cells
Disease Models and Mechanisms
LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells
Haematologica
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