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Allergies including asthma and hay fever not linked to mental health traits

Press release issued: 6 October 2021

Allergic diseases such as asthma, atopic dermatitis and hay fever do not cause the onset of mental health conditions or vice versa, according to the findings of a new University of Bristol-led study published today (6 October) in the journal Clinical and Experimental Allergy.

While previous studies have reported an observational relationship between mental health and common allergic diseases, until now, causal relationships had not yet been identified.

Researchers from Bristol Medical School: Population Health Sciences (PHS) and School of Psychological Science wanted to find out whether allergic diseases actually cause mental health traits including anxiety, depression, bipolar disorder and schizophrenia or vice-versa.

First, the team of researchers sought to isolate the effects of these allergic diseases by applying a scientific technique called Mendelian Randomisation, which allowed them to identify genetic variants linked to these allergic diseases and then investigated how these variants were causally related to the presence of mental health conditions based on a sample of 12,000-344,901 individuals.

Although researchers identified observational associations between allergic disease and mental health traits, these were not replicated in the team’s causal analysis.  Little evidence of a causal relationship between the onset of allergic disease and mental health was found suggesting that the observational associations found were due to confounding or other forms of bias.

The authors conclude that intervening on the initial presentation of allergic disease is unlikely to improve mental health outcomes. Likewise, preventing the onset of mental health traits will unlikely reduce the risk of allergic disease. However, further research is required to investigate whether intervening on the progression of allergic disease after onset has any causal impact on mental health.

Dr Ashley Budu-Aggrey, Senior Research Associate at Bristol Medical School: PHS and the study’s lead author said: “Common mental health disorders such as anxiety and depression are some of the largest contributors to the global burden of disease and the prevalence of these and allergic disease has been increasing for some time. Disentangling the nature of the relationship between allergic disease and mental health helps answer an important health question and suggests that the onset of allergic disease does not cause the onset of mental health traits or vice versa.

“This however does not rule out a potential causal effect upon the progression of disease which is yet to be investigated and could help uncover novel treatment strategies for allergic disease or mental health traits.”

Senior author Dr Hannah Sallis, Senior Research Associate in Bristol’s School of Psychological Science added: “The research used a combination of approaches and data from several studies. This helps to strengthen our confidence in the findings. Establishing whether allergic disease causes mental health problems, or vice versa, is important to ensure that resources and treatment strategies are targeted appropriately.”

The study was funded through grants from the Medical Research Council (MRC), European Research Council (ERC), National Institute for Health Research Bristol Biomedical Research Centre (NIHR Bristol BRC), Norwegian Research Council, British Skin Foundation and the Academy of Medical Sciences Springboard Award, which is supported by the Wellcome Trust, Department for Business, Energy and Industrial Strategy, Global Challenges Research Fund and the British Heart Foundation.


'Investigating the causal relationship between allergic disease and mental health' by A Budu-Aggrey et al in Clinical and Experimental Allergy

Further information

About Mendelian Randomization

Information on Mendelian Randomization: a method of using variation in genes of known function between people to examine the causal effect of a modifiable exposure ( on disease (i.e.cancer) in observational studies. The use of genetics takes away any potential measurement, or human, error associated with questionnaires and participant recall which are often used to record lifestyle factors such as level of physical activity.

About UK Biobank

UK Biobank is a major national and international health resource, and a registered charity in its own right with the aim of improving the prevention, diagnosis and treatment of a wide range of serious and life-threatening illnesses – including cancer, heart diseases, stroke, diabetes, arthritis, osteoporosis, eye disorders, depression and forms of dementia. UK Biobank recruited 500,000 people aged between 40-69 years in 2006-2010 from across the country to take part in this project. They have undergone measures, provided blood, urine and saliva samples for future analysis, detailed information about themselves and agreed to have their health followed. Over many years this will build into a powerful resource to help scientists discover why some people develop particular diseases and others do not.

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