2022 Publications

The EWAS Catalog: a database of epigenome-wide association studies 

Battram, T., Yousefi, P., Crawford, G., Prince, C., Sheikhali Babaei, M., Sharp, G., Hatcher, C., Vega-Salas, M. J., Khodabakhsh, S., Whitehurst, O., Langdon, R., Mahoney, L., Elliott, H. R., Mancano, G., Lee, M. A., Watkins, S. H., Lay, A. C., Hemani, G., Gaunt, T. R., Relton, C. L.& 2 others, , 31 May 2022, Wellcome Open Research. 7. 

Interaction-based Mendelian randomization with measured and unmeasured gene-by-covariate interactions 

Spiller, W., Sanderson, E. C. M., Pires Hartwig, F., Davey Smith, G. & Bowden, J., 10 Aug 2022, PLoS ONE. 17, 8. 

Alcohol and hypertensive disorders of pregnancy: a negative control analysis 

Martin, F., Fraser, A. & Zuccolo, L., 29 Oct 2022, Journal of the American Heart Association. 

 

Examining Health Outcomes in Juvenile Idiopathic Arthritis: A Genetic Epidemiology Study 

Clarke, S. L. N., Richmond, R., Zheng, J.,Spiller, W., Ramanan, A. V., Sharp, G. C. & Relton, C. L., 25 Jan 2022, ACR Open Rheumatology. 4, 4. 

Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer’s disease 

Pagoni, P., Dardani, C.,Leppert, B., Korologou-Linden, R. S., Davey Smith, G., Howe, L. D., Anderson, E. L. & Stergiakouli,E., 1 Oct 2022,Translational Psychiatry. 12, 1, 422. 

Genetic liability to rheumatoid arthritis on autism and autistic traits: polygenic risk score and mendelian randomization analyses 

Ly, A., Leppert, B., Rai, D., Jones, H. J.,Dardani, C. & Stergiakouli, E., 12 Jan 2022, Translational Psychiatry. 12. 

Parental inflammatory bowel disease and autism in children: Triangulating the evidence using four complementary study designs 

Sadik, A. A. S.,Dardani, C., Pagoni, P., Havdahl, K. A., Stergiakouli, E., Grove, J., Khandaker, G. M., Sullivan, S. A., Zammit, S., Jones, H. F., Davey Smith, G., Dalman, C., Karlsson, H., Gardner, R. M. & Rai, D., 2 Jun 2022, Nature Medicine. 28, 7. 

Exploring and mitigating potential bias when genetic instrumental variables are associated with multiple non-exposure traits in Mendelian randomization 

Yang, Q., Sanderson, E. C. M., Tilling, K. M., Borges, M. C. & Lawlor, D. A., 27 May 2022,European Journal of Epidemiology. 

  

Investigating causal relations between sleep duration and risks of adverse pregnancy and perinatal outcomes: linear and nonlinear Mendelian randomization analyses 

Yang, Q., Magnus, M. C., Kilpi, F. C., Santorelli, G., Goncalves Soares, A. L., West, J., Magnus, P., Wright, J., Haberg, S., Sanderson, E. C. M., Lawlor, D. A., Tilling, K. M. & Borges, M. C., 12 Sep 2022, BMC Medicine. 20, 1. 

Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimer's disease risk in the general population: a Mendelian randomisation study 

Zheng, J., Xu, M., Walker, V., Yuan, J.,Korologou-Linden, R., Robinson, J., Huang, P., Burgess, S., Au Yeung, S. L., Luo, S., Holmes, M. V., Davey Smith, G., Ning, G., Wang, W., Gaunt, T. R.& Bi, Y., 1 Oct 2022, Diabetologia. 65, 10. 

The causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomization 

Korologou-Linden, R. S., Bhatta, L.,Brumpton, B. M., Howe, L. D., Millard, L. A. C., Kolaric, K., Ben-Shlomo, Y., Williams, D. M., Davey Smith, G., Anderson, E. L., Stergiakouli, E. & Davies, N. M., 11 Aug 2022, Nature Communications. 13. 

Workplace interventions that aim to improve employee health and well-being in male-dominated industries: a systematic review 

Hulls, P. M., Richmond, R., Martin, R. M., Chavez Ugalde, Y. & de Vocht, F., 13 Jan 2022, Occupational and Environmental Medicine. 79, 2. 

The relationships between women’s reproductive factors: a Mendelian randomisation analysis 

Prince, C., Sharp, G. C.,Howe, L. D., Fraser, A. & Richmond, R., 24 Mar 2022, BMC Medicine. 20, 1. 

Evaluating and implementing block jackknife resampling Mendelian randomization to mitigate bias induced by overlapping samples 

Fang, S., Hemani, G., Richardson, T. G., Gaunt, T. R. & Davey Smith, G., 6 Aug 2022, Human Molecular Genetics. 

Constructing an atlas of associations between polygenic scores from across the human phenome and circulating metabolic biomarkers 

Fang, S., Holmes, M. V., Gaunt, T. R., Davey Smith, G. & Richardson, T. G., 11 Oct 2022, eLife. 

A multivariant recall-by-genotype study of the metabolomic signature of BMI 

Fang, S., Wade, K. H., Hughes, D. A., FitzGibbon, S. J., Yip, V. L., Timpson, N. J. & Corbin, L. J., Oct 2022, Obesity. 30, 6. 

Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approach 

Richardson, T. G., Crouch, D., Power, G. M.,Morales Berstein, F., Hazelwood, E.,Fang, S., Cho, Y., Inshaw, J., Robertson, C., Sidore, C., Cucca, F., Rich, S., Todd, J. & Davey Smith, G., 28 Apr 2022, Nature Communications. 13, 1, 2337. 

Mendelian randomization study of maternal coffee consumption and its influence on birthweight, stillbirth, miscarriage, gestational age and pre-term birth 

Nunes, C. B.,Huang, P., Wang, G., Lundberg, M., D'Urso, S., Wootton, R. E., Borges, M. C., Lawlor, D. A., Warrington, N. M., Evans, D., Hwang, D. L-D. & Moen, G-H., 9 Jun 2022, International Journal of Epidemiology. 

Alcohol intake and hypertensive disorders of pregnancy: a negative control analysis in the ALSPAC cohort 

Martin, F., Fraser, A. & Zuccolo, L., 29 Sep 2022, Journal of the American Heart Association. 11, 19. 

Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study 

Morales-Berstein, F., McCartney, D. L., Lu, A. T., Tsilidis, K. K., Bouras, E., Haycock, P., Burrows, K., Phipps, A. I., Buchanan, D. D., Cheng, I., Martin, R. M., Smith, G. D., Relton, C. L., Horvath, S., Marioni, R. E., Richardson, T. G. & Richmond, R. C., 29 Mar 2022, eLife. 

Pharmacoepidemiology in pregnancy: analysis protocol for an observational cohort study in the UK Clinical Practice Research Datalink 

Barry, C-J., Burden, C., Davies, N. & Walker, V., 12 Jan 2022, Wellcome Open Research. 

Comparison of intergenerational instrumental variable analyses of body mass index and mortality in UK Biobank 

Barry, C-J. S., Carslake, D. J., Wade, K. H., Sanderson, E. C. M. & Davey Smith, G., 10 Aug 2022,International Journal of Epidemiology. 

Using Mendelian Randomisation to Prioritise Candidate Maternal Metabolic Traits Influencing Offspring Birthweight 

Barry, C-J. S., Lawlor, D. A., Shapland, C. Y., Sanderson, E. C. M. & Borges, M. C., 10 Jun 2022, Metabolites. 12, 6, 537. 

Investigating how the accuracy of teacher expectations of pupil performance relate to socioeconomic and genetic factors 

Barry, C-J. S., Morris, T. T. & Davies, N. M., 3 May 2022, Scientific Reports. 12, 1. 

The metabolomic consequences of the Diabetes Remission Clinical Trial (DiRECT): characterising the intermediate biological effects of weight loss 

Corbin, L. J., Hughes, D. A., Bull, C. J., Vincent, E. E.,Smith, M. L., McConnachie, A., Messow, C-M., Welsh, P., Taylor, R., Lean, M. E. J., Sattar, N. & Timpson, N. J., 17 July 2022, Cell Metabolism. 

Distinct metabolic features of genetic liability to type 2 diabetes and coronary artery disease: a reverse Mendelian randomization study 

Smith, M. L., Bull, C. J., Holmes, M. V., Davey Smith, G., Anderson, E. L. & Bell, J. A., Jul 2022, IGES 2022. 

Socioeconomic position and adverse childhood experiences as risk factors for health-related behavior change and employment adversity during the COVID-19 pandemic: insights from a prospective cohort study in the UK 

Smith, M. L., Herbert, A., Hughes, A., Northstone, K. & Howe, L. D., 24 Sep 2022, BMC Public Health.