Hosted by the School of Medicine at Cardiff University
The eukaryotic nucleus is a double membraned organelle housing the genome. This lecture will provide a holistic overview of how the structure of the nucleus influences genome function and how the epigenome fits within cellular signalling pathways to enable cells to respond to external environmental stimuli. I will shed light on how the epigenome really responds to the extracellular environment.
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Professor Adele Murrell is a prominent figure in the field of epigenetics. She is a Professor in the Department of Life Sciences at the University of Bath. Her research focuses on understanding how cells establish and maintain their specific identities, particularly how gene expression is regulated and how this process can go awry in cancer. The overarching research theme is to understand how cells establish and maintain their specific identities. Thus, what are the factors that control and enable genes to be expressed in one type of cell and not another? How does this go wrong in cancer and can we reprogramme gene expression or even reset it back to a stem cell state? Key areas of research include: Genomic Imprinting, Long range epigenetic gene regulation, and Epigenetic reprogramming during development and cancer metastasis.