Join us at the first edition of the Cancer Grand Challenges Conference Series, where we'll be convening researchers around the globe to discuss extrachromosomal DNA (ecDNA) — a field that Cancer Grand Challenges put in the spotlight, setting the extrachromosomal DNA challenge in 2020, and funding team eDyNAmiC, led by Paul Mischel.

ecDNA has emerged as one of the most pressing and challenging problems in cancer. ecDNAs, oncogene-containing circular DNA fragments found outside of chromosomes, play a crucial role in cancer development and progression. ecDNAs allow cancer cells to quickly evolve and adapt to changing environments and treatments, and thus are a significant clinical problem, as major contributors to treatment resistance and poor outcome. Conceptually ecDNA biology is fascinating – sitting at the interface of genetics and epigenetics. ecDNA biology is also vitally relevant - being linked to treatment resistance and poor outcome in patients. Understanding and exploiting ecDNA biology promises to transform the fundamental understanding of cancer and potentially revolutionise its treatment.

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