A Snapshot seminar hosted by the School of Physiology, Pharmacology and Neuroscience
Abstract: We describe and characterise a subset of tumour associated macrophages (TAMs) identified by their expression of LYVE-1 and HO-1 which reside in CCR5-dependent nests proximal to blood vasculature in cancer. Depletion approaches for this subset slow tumour growth in a spontaneous murine model of breast cancer. Our data highlight that this subset is associated with the immunological ‘heat’ and immune suppression in the tumour which influences the effectiveness of chemotherapy against cancer.