Hosted by the European Association for Cancer Research

All cancer tissue phenotypes are initiated by deregulated signaling mechanisms in cancer cells. Signaling mechanism are also the largest target mechanism entity for targeted cancer therapies. Recent data further strongly indicate that cancer therapy resistance is initiated by non-genetic signaling rewiring via post-translational regulation of proteins involved in signaling networks, and transcriptional gene regulation.

However, regardless of decades of research, our global understanding of how cancer cell signaling circuits are controlled, and how they determine cancer progression and therapy resistance is still far from complete.

This conference will focus on basic mechanisms controlling cancer cell signaling circuits at the epigenome, transcriptome, proteome and phosphoproteome levels. The talks will also focus on therapeutic targeting of cancer cell signaling circuits by conventional and emerging pharmacological strategies.

Topics to be covered:

• Kinases and phosphatases
• Transcriptional and epigenetic gene regulation
• Non-genetic signaling rewiring
• Cancer cell plasticity
• Proteogenomic signal integration

Abstract submission deadline: 5 January 2024

More information and to register (closes 29 January 2024)