Hosted by the School of Medicine at Cardiff University
Nicolas Manel has been the Head of the Innate Immunity Team at Curie Institute since 2010 and INSERM Research Director since 2014. Innate immunity is an ancient and universal form of defence against damages, threats and pathogens such as viruses. How the innate immunity distinguishes self from non-self (e.g. viruses) inside cells remains poorly understood. As a result, the ability to exploit innate immunity for anti-viral treatments, vaccines or cancer immunotherapy has remained limited.
The Manel lab investigates the regulation, function and application of innate immunity, with the goal to discover the molecular mechanisms that enable the immune system to distinguish self from non-self inside cells. They study HIV, other viruses and auto-immunity and development of the immune system. The lab uses primary human immune cells, mouse models, cell lines and computational tools, and they develop applications of our research for clinical use. Specific topics of interests are:
- Innate immune sensing and replication of HIV & other viruses
- Activation of the cGAS-STING pathway by self & non-self
- Functions of the nuclear envelope in viral replication and host defense
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