Hosted by the School of Biochemistry
ABSTRACT: Acute Promyelocytic Leukaemia is caused by a chromosomal translocation that fuses the genes encoding Promyelocytic Leukaemia (PMI) protein and retinoic acid receptor alpha (RARA). However, most patients are now cured by treatment with arsenic trioxide (ATO). I will discuss how SUMO and ubiquitin modifications induced by arsenic lead to targeted degradation of the PML-RARA oncogene and cure of the disease.