Hosted by the School of Medicine at Cardiff University

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Immune regulatory functions of Group 2 Innate Lymphoid Cells:

• ILC2 are important mediators of innate and adaptive type-2 immunity, but have other emerging functions
• ILC2 can directly regulate regulatory T cells via the OX40L-OX40 signalling axis in diverse anatomical sites
• ILC2 antagonize anti-metastatic function of NK cells in the lung via eosinophil-mediated metabolic rewiring of the local environment
• Unpublished data will also be presented

Dr. Tim Halim received his PhD from the University of British Columbia and continued his postdoctoral studies at the MRC Laboratory of Molecular Biology. During his training as an immunologist, he uncovered a role of newly discovered group 2 innate lymphoid cells in allergic airway inflammation, and further identified mechanisms by which these cells interact with CD4 T cells of the adaptive immune system. He joined the faculty at the Cancer Research UK Cambridge Institute with additional support of a Wellcome Trust Sir Henry Dale Fellowship in 2017 with the aim of investigating the immune-regulatory role of ILC2 in cancer. The Halim laboratory focusses on innate lymphoid cell (ILC) biology, and how innate immunity interacts locally with immune and non-immune cells in the pancreas. Their goal is to elucidate how the local environment influences both disease and normal tissue behaviour, with an aim to exploit these organ-specific features for more targeted drug interventions.