The immunology of long-haul disease

Bristol Beacon

Hosted by the British Society for Immunology Bristol Immunology Group

Innate and adaptive arms of the immune response together orchestrate the effective control of acute infection. However, in an endeavour to restore tissue homeostasis, it is increasingly clear that the immune system plays a long game in its negotiations with foreign, tumour and self-antigens that expose us to chronic disease. Infection and its sequelae, the immunosurveillance of cancer, and dysfunctional immunity manifesting as autoimmunity all show an evolution in immune function through time.

This one-day event, organised by the BSI Bristol Immunology Group, will present current research in these areas highlighting immunological mechanisms that evolve during the development and progression of disease.

Programme:

Session 1

Infection and Immunopathology
Chairs – Laura Rivino, Simon Eastham
9:20 Welcome and opening remarks – Lindsay Nicholson
9:30

Sarah Rowland-Jones, University Oxford
Comorbidities in African adolescents with perinatally-acquired HIV infection – a tale of two
viruses?
9:55

Borko Amulic, University of Bristol
Neutrophils as protagonists in severe malaria
10:20

Laura Pallett, UCL
CD14 marks tissue CD8+ T-cells instructed by myeloid cells and modulated by LPS
10:40

Shishir Shetty, University of Birmingham
The senescent secretome promotes expression of the fetal receptor PLVAP in human hepatic
endothelium to promote monocyte transmigration
11:00 Refreshment Break, posters and exhibition
Session 2

Autoimmunity, Inflammation and Immune Privilege
Chairs - Lindsay Nicholson, Claire Naveh
11:25

Lucy Walker, UCL
Fine tuning costimulation blockade in autoimmunity
11:50

David Wraith, University of Birmingham
Antigen-specific immune intervention in long-haul autoimmune disease
12:10

Ben Jenkins, Swansea University
Canagliflozin impairs T-cell effector function via metabolic suppression in autoimmunity
12:30

David Copland, University of Bristol
IL-23 drives uveitis by acting on a novel population of resident ocular T cells
12:50 Lunch, posters and exhibition
Session 3

Cancer Immunology
Chairs – Gareth Jones, Michaela Gregorova
14:15

Awen Gallimore, Cardiff University
Breaking down multiple barriers to tumour immunity: how to trigger the perfect storm
14:40

Maike De La Roche, University of Cambridge
Hedgehog signaling in immune cells: novel biology and treatment opportunities
15:05

Jessica Oliver, Cardiff University
Investigating the impact of radiation on the immunopeptidome of colorectal cancer cell lines
15:25

Hanin Alamir, University of Bristol
TIM3 is a context-dependent co-regulator of cytotoxic T cell function
15:45 Refreshment break
16:00

Keynote: Peter Openshaw, Imperial College London
What we’ve learnt about immune inflammation and defence from studies of COVID
16:45

Concluding remarks, Laura Rivino
Networking reception

More information and to register

Contact information

Enquiries to meetings@immunology.org