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Carlos Caldas is Professor of Cancer Medicine at the University of Cambridge, and Head of the Breast Cancer Functional Genomics Laboratory at the Cancer Research UK Cambridge Institute. He is an Honorary Consultant Medical Oncologist and was the Founding Director of the Breast Cancer Programme at the Cambridge Cancer Centre. He has published over 450 manuscripts, including in Nature, New England Journal of Medicine, Nature Genetics, Nature Medicine, Nature Cancer, Cell, Cancer Cell. His research focus is the functional genomics of breast cancer and its biological and clinical implications. His laboratory redefined the molecular taxonomy of breast cancer, revealing novel subtypes and their respective drivers and multi-omic landscapes, robustly validated this new molecular taxonomy, and showed that it determines the clinical trajectories of patients. He led the studies that established ctDNA as a monitoring biomarker in breast cancer and as a liquid biopsy to unravel therapy resistance. His laboratory pioneered and developed the use of patient-derived tumour explants as models of breast cancer, in particular as a platform to characterize and perturb tumour ecosystems. In a recent landmark paper published in Nature his group showed, using multi-omics and machine learning, the biology of breast tumour ecosystems determines response to therapy.