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The precise spatial localization of molecular signals within tissues richly informs the mechanisms of tissue formation and function. Here, we’ll introduce Slide-seq, a technology which enables transcriptome-wide measurements with near-single cell spatial resolution. We’ll describe recent experimental and computational advances to enable Slide-seq in biological contexts in biological contexts where high detection sensitivity is important. More broadly, we’ll discuss the promise and challenges of spatial transcriptomics for tissue genomics.
Dr. Fei Chen is a core institute member at the Broad Institute of MIT and Harvard and an assistant professor in the Department of Stem Cell and Regenerative Biology at Harvard University. During the course of his doctoral research, Chen co-invented Expansion Microscopy, a breakthrough technique that allows for super-resolution imaging of biological samples with conventional light microscopes. As an independent fellow at the Broad Institute, he led a group which bridged microscopy with next generation sequencing through in situ sequencing and Slide-seq technologies. In his current group, he continues to pioneer novel molecular and microscopy tools to uniquely illuminate biological pathways and function.