Hosted by the School of Medicine at Cardiff University
Cell death is an invariant feature throughout our lifespan, starting with extensive scheduled cell death during morphogenesis and continuing with death under homeostasis in adult tissues. Additionally, cells become victims of accidental, unscheduled death following injury and infection. Cell death in each of these occasions triggers specific and specialized responses in the living cells that surround them or are attracted to the dying/dead cells. These responses sculpt tissues during morphogenesis, replenish lost cells in homeostasis to maintain tissue/system function, and repair damaged tissues after injury. Wherein lies the information that sets in motion the cascade of effector responses culminating in remodeling, renewal or repair? I will attempt to provide a framework for thinking about cell death in terms of the specific effector responses that accompanies various modalities of cell death. I will also propose an integrated three-fold “cell death code” consisting of information intrinsic to the dying/dead cell, the surroundings of the dying cell and the identity of the responder.
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Prof. Carla V. Rothlin is an Argentinian immunologist and Dorys McConnell Duberg Professor of Immunobiology and Professor of Pharmacology at Yale University. Prof. Rothlin co-directs a laboratory together with Sourav Ghosh, Ph.D., Associate Professor of Neurology and Pharmacology. Their research focuses on mechanisms that underlie the regulation of inflammation and the homeostatic control of immune function. She is also the co-leader of the Cancer Immunology Program at the Yale Cancer Center. She is highly committed to Yale’s education mission and was appointed Director of Graduate Studies in Immunobiology in 2018. She is also one of the co-founders and lead organizers of Global Immunotalks, a weekly seminar series delivered by thought leaders in all areas of fundamental immunology. The series aims at helping to close the gap between those in the scientific community who have regular access to these kinds of talks and those who do not.