Hosted by the School of Medicine at Cardiff University
Neutrophils save our lives every day. They do it silently and effectively, as they detect, migrate towards, and kill potential pathogens. Precisely because they do this task so efficiently, it has been difficult to recognize (and have tools to do so) other aspects of their physiology. As a field we have recently learnt that they are important effectors of non-infectious, physiological programs such as antigen presentation or angiogenesis, and even in prominent pathologies like cancer and neurodegeneration. We are interested in understanding these non-canonical functions of neutrophils that extend their essential role in immune surveillance. I will present our published and current efforts to discover new functions across different physiological contexts and locations, and discuss how this is providing new dimensions to the biology of these fascinating leukocytes.
Andres Hidalgo is a Full Professor at Yale University and at The National Centre for Cardiovascular Research (CNIC) in Spain. His research interests have focused on the cellular and molecular mechanisms by which innate immune cells, and their hematopoietic precursors, contribute to organismal physiology and pathology. At CNIC, his laboratory developed live imaging technologies and applied them to the study of thrombo-inflammation and the dramatic consequences in several organs, including the lung, brain and heart. The Hidalgo Laboratory discovered new functions for innate immune cells, and demonstrated that circadian rhythms in the bone marrow are entrained in part by neutrophils entering this organ. They have been also interested in defining the immune circadian clockworks that control leukocyte functions, and underlies circadian defense and inflammation. They have extended their analyses to tissue resident macrophages to the heart, and used imaging to identify mechanisms of mitochondrial homeostasis.
- https://cardiff.zoom.us/j/84907557608?pwd=LzNuY1psVkwvcS8rbzY0bWsxZW40QT09
- Meeting ID: 849 0755 7608
- Password: 725468