Proteins that interact with glutamate receptors

Over the last few years, first with the advent of yeast 2-hybrid technology and then with improved immunoprecipitation techniques and the development of proteomics, it has become clear that receptor proteins operate within a complex web of interactions with other proteins that goes far beyond well known phosphorylation and dephosphorylation cycles. Many interactions serve to modulate the transport, localisation and mobility of receptor molecules, while others affect their acute functioning. Many proteins have been found that interact directly with glutamate receptors (some with more than one subtype), while many more interact indirectly. This gives rise to vast and complex network of protein-protein interactions that can have a profound effect on synaptic function.

The table shows the major interacting proteins for each class of glutamate receptor while the links to following pages detail three structure and functions. These do not include the protein kinases and phosphatases that perform (de)phosphorylation on these proteins, as numerous such interaction sites exits on each receptor subunit/type.

 AMPA ReceptorsKainate ReceptorsNMDA ReceptorsmGlu Receptors
ABP/GRIP Interaction between ABP/GRIP and AMPA Receptors Interactions between GRIP and kainate Receptors   yes
AKAPs yes   Interactions between AKAPs and NMDA receptors  
AP-2 Interactions between AP2 and AMPA Receptors   Interactions between AP2 and NMDA Receptors  
Homer       yes
NET O2   yes    
NSF Interactions between NSF and AMPA Receptors      
PICK1 Interactions between PICK1 and AMPA receptors Interactions between PICK1 and kainate Receptors   yes
PSD95 Interactions between PSD95 and AMPA Receptors   Interactions between PSD95 and NMDA Receptors  
SAP97 Interactions between SAP97 and AMPA Receptors      
SAP102     Interactions between SAP102 and NMDA Receptors yes
SUMO   Interactions between SUMO and kainate Receptors    
TARP Interactions between TARPS and AMPA Receptors