The original QUADAS tool consists of 14 items each of which is rated as "yes", "no", or "unclear", with "yes" always indicating a good response. QUADAS covers risk of bias, applicability and reporting quality. The Cochrane version of the tool omitted items relating to quality of reporting (shown in italics).
|1.||Was the spectrum of patients representative of the patients who will receive the test in practice?|
|2.||Were selection criteria clearly described?|
|3.||Is the reference standard likely to correctly classify the target condition?|
|4.||Is the time period between reference standard and index test short enough to be reasonably sure that the target condition did not change between the two tests?|
|5.||Did the whole sample or a random selection of the sample, receive verification using a reference standard of diagnosis?|
|6.||Did patients receive the same reference standard regardless of the index test result?|
|7.||Was the reference standard independent of the index test (i.e. the index test did not form part of the reference standard)?|
|8.||Was the execution of the index test described in sufficient detail to permit replication of the test?|
|9.||Was the execution of the reference standard described in sufficient detail to permit its replication?|
|10.||Were the index test results interpreted without knowledge of the results of the reference standard?|
|11.||Were the reference standard results interpreted without knowledge of the results of the index test?|
|12.||Were the same clinical data available when test results were interpreted as would be available when the test is used in practice?|
|13.||Were uninterpretable/ intermediate test results reported?|
|14.||Were withdrawals from the study explained?|
Full details of the QUADAS tool together with the background document detailing how to apply it in a systematic review were published in BioMed Central Medical Research Methodology and as an HTA report.