New materials for targeted vaccine delivery

Researchers at Bristol have developed a toolkit of α-helical coiled coil peptide modules as building blocks for creating self-assembling biomimetic structures. The latest designed structures are hollow spheres (~100 nm in diameter) constructed from simple peptide modules, which when mixed form hexagonal lattices that close to form cages. The new structures (SAGEs) mimic those in natural en-capsulation systems, like virus capsids. The SAGEs offer the poten-tial for simple, reproducible presentation and/or encapsulation and release systems for controlled delivery of vaccines and drugs.

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