David Wynick
d.wynick@bristol.ac.ukProfessor of Molecular Medicine
Joint Director of Research NBT and UHBristol NHS Trusts
+44 (0) 117 331 1417
Research
The research strategy of my group over the last 15 years has been to advance our understanding of the molecular and cellular mechanisms that underlie the adaptive response of the nervous system to injury. We have used a number of genomic and proteomic screens to identify novel therapeutic targets for various forms of peripheral sensory neuropathies and associated chronic pain conditions. These targets include galanin and its second receptor subtype GalR2, sodium channel splice variants and the chemokine fractalkine and its receptor CX3CR1. We have applied a variety of complementary molecular, cellular, transgenic and behavioural technologies to study the expression and function of these genes in the peripheral and central nervous systems. Most recently we have started to develop small molecule drug-like allosteric modulators of GalR2 funded by a Wellcome Trust Seeding Drug Discovery award focused on the treatment of neuropathic pain and various neurodegenerative conditions including Alzheimer's disease and multiple sclerosis.
Group Members
Selected Publications
- Pope, R. J., Holmes, F. E., Kerr, N. C., and Wynick, D. (2010) Characterisation of the nociceptive phenotype of suppressible galanin overexpressing transgenic mice. Mol.Pain. 6, 67
- Wraith, D. C., Pope, R., Butzkueven, H., Holder, H., Vanderplank, P., Lowrey, P., Day, M. J., Gundlach, A. L., Kilpatrick, T. J., Scolding, N., and Wynick, D. (2009) A role for galanin in human and experimental inflammatory demyelination. Proceedings of the National Academy of Sciences of the United States of America. 106, 15466-15471
- Holmes, F. E., Arnott, N., Vanderplank, P., Kerr, N. C., Longbrake, E. E., Popovich, P. G., Imai, T., Combadiere, C., Murphy, P. M., and Wynick, D. (2008) Intra-neural administration of fractalkine attenuates neuropathic pain-related behaviour. Journal of Neurochemistry. 106, 640-649
- Hulse, R., Wynick, D., and Donaldson, L. F. (2008)Characterization of a novel neuropathic pain model in mice. Neuroreport. 19, 825-829
- Kerr, N. C., Holmes, F. E., and Wynick, D. (2008) Novel mRNA isoforms of the sodium channels Na(v)1.2, Na(v)1.3 and Na(v)1.7 encode predicted two-domain, truncated proteins. Neuroscience. 155, 797-808
- Elliott-Hunt, C. R., Pope, R. J., Vanderplank, P., and Wynick, D. (2007) Activation of the galanin receptor 2 (GalR2) protects the hippocampus from neuronal damage. J.Neurochem. 100, 780-789
- Kerr, N. C., Gao, Z., Holmes, F. E., Hobson, S. A., Hancox, J. C., Wynick, D., and James, A. F. (2007) The sodium channel Na(v)1.5a is the predominant isoform expressed in adult mouse dorsal root ganglia and exhibits distinct inactivation properties from the full-length Na(v)1.5 channel. Molecular & Cellular Neurosciences. 35, 283-291
- Hobson, S. A., Holmes, F. E., Kerr, N. C. H., Pope, R. J., and Wynick, D. (2006) Mice deficient for galanin receptor 2 have decreased neurite outgrowth from adult sensory neurons and impaired pain-like behaviour. J.Neurochem. 99, 1000-1010.
- Elliott-Hunt, C. R., Marsh, B., Bacon, A., Pope, R., Vanderplank, P., and Wynick, D. (2004) Galanin acts as a neuroprotective factor to the hippocampus. Proc Natl Acad Sci USA. 101, 5105-5110
- Holmes, F. E., Bacon, A., Pope, R. J., Vanderplank, P. A., Kerr, N.C., Sukumaran, M., Pachnis, V., and Wynick, D. (2003) Transgenic overexpression of galanin in the dorsal root ganglia modulates pain-related behavior. Proc Natl Acad Sci USA. 100, 6180-6185
- Mahoney, S. A., Hosking, R., Farrant, S., Holmes, F. E., Jacoby, A.S., Shine, J., Iismaa, T. P., Scott, M. K., Schmidt, R., and Wynick, D. (2003) The second galanin receptor GalR2 plays a key role in neurite outgrowth from adult sensory neurons. Journal Of Neuroscience. 23, 416-421
For a complete list of publications please click on 'link' below
Publications link
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